eF-site ID 5fgk-A PDB Code 5fgk Chain A click to enlarge Title CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one Classification TRANSFERASE Compound Cyclin-dependent kinase 8 Source Homo sapiens (Human) (CCNC_HUMAN) Sequence A:  MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKR KDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVIS LQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRAVQLPRGM VKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERG RVKIADMGFAVTFWYRAPELLLGARHYTKAIDIWAIGCIF AELLTSEPIFHCRQPYHHDQLDRIFNVMGFPADKDWEDIK KMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHL LQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQI PYPKREFLTEE Description (1)  Cyclin-dependent kinase 8 (E.C.2.7.11.22,2.7.11.23), Cyclin-C Functional site 1) chain A residue 27 type sequence V description binding site for residue 5XG A 401 source : AC1 2) chain A residue 32 type sequence Y description binding site for residue 5XG A 401 source : AC1 3) chain A residue 50 type sequence A description binding site for residue 5XG A 401 source : AC1 4) chain A residue 52 type sequence K description binding site for residue 5XG A 401 source : AC1 5) chain A residue 79 type sequence I description binding site for residue 5XG A 401 source : AC1 6) chain A residue 98 type sequence D description binding site for residue 5XG A 401 source : AC1 7) chain A residue 100 type sequence A description binding site for residue 5XG A 401 source : AC1 8) chain A residue 158 type sequence L description binding site for residue 5XG A 401 source : AC1 9) chain A residue 173 type sequence D description binding site for residue 5XG A 401 source : AC1 10) chain A residue 356 type sequence R description binding site for residue 5XG A 401 source : AC1 11) chain A residue 66 type sequence E description binding site for residue DMS A 402 source : AC2 12) chain A residue 79 type sequence I description binding site for residue DMS A 402 source : AC2 13) chain A residue 172 type sequence A description binding site for residue DMS A 402 source : AC2 14) chain A residue 173 type sequence D description binding site for residue DMS A 402 source : AC2 15) chain A residue 174 type sequence M description binding site for residue DMS A 402 source : AC2 16) chain A residue 176 type sequence F description binding site for residue DMS A 402 source : AC2 17) chain A residue 124 type sequence P description binding site for residue EDO A 403 source : AC3 18) chain A residue 126 type sequence G description binding site for residue EDO A 403 source : AC3 19) chain A residue 122 type sequence Q description binding site for residue FMT A 404 source : AC4 20) chain A residue 125 type sequence R description binding site for residue FMT A 404 source : AC4 21) chain A residue 228 type sequence L description binding site for residue FMT A 404 source : AC4 22) chain A residue 125 type sequence R description binding site for residue FMT A 405 source : AC5 23) chain A residue 302 type sequence V description binding site for residue FMT A 405 source : AC5 24) chain A residue 303 type sequence K description binding site for residue FMT A 405 source : AC5 25) chain A residue 306 type sequence S description binding site for residue FMT A 405 source : AC5 26) chain A residue 143 type sequence H description binding site for residue FMT A 406 source : AC6 27) chain A residue 144 type sequence A description binding site for residue FMT A 406 source : AC6 28) chain A residue 146 type sequence W description binding site for residue FMT A 406 source : AC6 29) chain A residue 213 type sequence K description binding site for residue FMT A 406 source : AC6 30) chain A residue 253 type sequence D description binding site for residue FMT A 407 source : AC7 31) chain A residue 254 type sequence R description binding site for residue FMT A 407 source : AC7 32) chain A residue 257 type sequence N description binding site for residue FMT A 407 source : AC7 33) chain A residue 54 type sequence I description binding site for residue FMT A 408 source : AC8 34) chain A residue 55 type sequence E description binding site for residue FMT A 408 source : AC8 35) chain A residue 56 type sequence G description binding site for residue FMT A 408 source : AC8 36) chain A residue 57 type sequence T description binding site for residue FMT A 408 source : AC8 37) chain A residue 58 type sequence G description binding site for residue FMT A 408 source : AC8 38) chain A residue 63 type sequence A description binding site for residue FMT A 408 source : AC8 39) chain A residue 21 type sequence E description binding site for residue FMT A 409 source : AC9 40) chain A residue 22 type sequence Y description binding site for residue FMT A 409 source : AC9 41) chain A residue 23 type sequence E description binding site for residue FMT A 409 source : AC9 42) chain A residue 150 type sequence R description binding site for residue EDO A 410 source : AD1 43) chain A residue 175 type sequence G description binding site for residue EDO A 410 source : AD1 44) chain A residue 200 type sequence R description binding site for residue EDO A 410 source : AD1 45) chain A residue 211 type sequence Y description binding site for residue EDO A 410 source : AD1 46) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 27-52 type prosite sequence VGRGTYGHVYKAKRKDGKDDKDYALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK source prosite : PS00107 48) chain A residue 147-159 type prosite sequence VLHRDLKPANILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV source prosite : PS00108 49) chain A residue 27 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 52 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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