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|
eF-site ID
|
5ffw-ABC |
|
PDB Code
|
5ffw |
|
Chain
|
A, B, C |
|
click to enlarge
|
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Title
|
Crystal structure of the bromodomain of human BRPF1 in complex with H4K5acK8ac histone peptide |
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Classification
|
TRANSCRIPTION |
|
Compound
|
Peregrin |
|
Source
|
Homo sapiens (Human) (Q0VAS5_HUMAN) |
|
|
Sequence
|
A: |
LTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHI
KKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNA
KDTIFYRAAVRLREQGGAVLRQARRQAEKM
|
| B: |
QLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDH
IKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYN
AKDTIFYRAAVRLREQGGAVLRQARRQAEKM
|
| C: |
SGRGXGGXGL
|
|
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Description
|
|
Functional site
|
|
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1)
|
chain |
A |
| residue |
650-707 |
| type |
prosite |
| sequence |
GNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLEAYRYLN
FDDFEEDFNLIVSNCLKY
|
| description |
BROMODOMAIN_1 Bromodomain signature. GniFsepvPlsevp..DYLdhIkkpMdfftMkqnleayr..Ylnfddfeedfnl.IvsNClkY
|
| source |
prosite : PS00633
|
|
|
2)
|
chain |
C |
| residue |
1 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:17967882
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
C |
| residue |
3 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
C |
| residue |
5 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
C |
| residue |
8 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|