eF-site ID 5fe8-AB PDB Code 5fe8 Chain A, B click to enlarge Title Crystal structure of human PCAF bromodomain in complex with compound SL1126 (compound 12) Classification SIGNALING PROTEIN Compound Histone acetyltransferase KAT2B Source Homo sapiens (Human) (KAT2B_HUMAN) Sequence A:  DPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEV IRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYN PPESEYYKCANILEKFFFSKIKEAGLID B:  DPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEV IRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYN PPESEYYKCANILEKFFFSKIKEAGLID Description Functional site 1) chain A residue 747 type sequence P description binding site for residue 5WT A 901 source : AC1 2) chain A residue 755 type sequence T description binding site for residue 5WT A 901 source : AC1 3) chain A residue 756 type sequence E description binding site for residue 5WT A 901 source : AC1 4) chain A residue 803 type sequence N description binding site for residue 5WT A 901 source : AC1 5) chain A residue 809 type sequence Y description binding site for residue 5WT A 901 source : AC1 6) chain A residue 761 type sequence Y description binding site for residue EDO A 902 source : AC2 7) chain A residue 830 type sequence I description binding site for residue EDO A 903 source : AC3 8) chain A residue 734 type sequence S description binding site for residue EDO A 905 source : AC5 9) chain A residue 738 type sequence Q description binding site for residue EDO A 905 source : AC5 10) chain A residue 823 type sequence K description binding site for residue EDO A 905 source : AC5 11) chain A residue 826 type sequence E description binding site for residue EDO A 905 source : AC5 12) chain A residue 827 type sequence A description binding site for residue EDO A 905 source : AC5 13) chain B residue 771 type sequence K description binding site for residue EDO B 901 source : AC6 14) chain B residue 774 type sequence S description binding site for residue EDO B 901 source : AC6 15) chain B residue 776 type sequence R description binding site for residue EDO B 902 source : AC7 16) chain B residue 727 type sequence Q description binding site for residue EDO B 903 source : AC8 17) chain B residue 728 type sequence L description binding site for residue EDO B 903 source : AC8 18) chain B residue 731 type sequence T description binding site for residue EDO B 903 source : AC8 19) chain A residue 775 type sequence E description binding site for residue EDO B 904 source : AC9 20) chain A residue 779 type sequence N description binding site for residue EDO B 904 source : AC9 21) chain B residue 776 type sequence R description binding site for residue EDO B 904 source : AC9 22) chain B residue 779 type sequence N description binding site for residue EDO B 904 source : AC9 23) chain B residue 747 type sequence P description binding site for residue DMS B 905 source : AD1 24) chain B residue 803 type sequence N description binding site for residue DMS B 905 source : AD1 25) chain A residue 745-802 type prosite sequence AWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVS KKLFMADLQRVFTNCKEY description BROMODOMAIN_1 Bromodomain signature. AwpFmepvKrteap..GYYevIrfpMdlktMserlknry..Yvskklfmadlqr.VftNCkeY source prosite : PS00633

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