eF-site ID 5fbc-A PDB Code 5fbc Chain A click to enlarge Title S1 nuclease from Aspergillus oryzae in complex with 2'-deoxyadenosine-5'-thio-monophosphate (5'dAMP(S)). Classification HYDROLASE Compound Nuclease S1 Source Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (NUS1_ASPOR) Sequence A:  WGNLGHETVAYIAQSFVASSTESFCQNILGDDSTSYLANV ATWADTYKYTDAGEFSKPYHFIDAQDNPPQSCGVDYDRDC GSAGCSISAIQNYTNILLESPNGSEALNALKFVVHIIGDI HQPLHDENLEAGGNGIDVTYDGETTNLHHIWDTNMPEEAA GGYSLSVAKTYADLLTERIKTGTYSSKKDSWTDGIDIKDP VSTSMIWAADANTYVCSTVLDDGLAYINSTDLSGEYYDKS QPVFEELIAKAGYRLAAWLDLIASQPS Description Functional site 1) chain A residue 237-248 type prosite sequence STVLDDGLAYIN description SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. STVLDDGLayiN source prosite : PS00136 2) chain A residue 21 type BINDING sequence W description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 3) chain A residue 26 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 4) chain A residue 80 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 5) chain A residue 135 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 6) chain A residue 139 type BINDING sequence D description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 7) chain A residue 145 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 8) chain A residue 168 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 9) chain A residue 172 type BINDING sequence D description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI1 10) chain A residue 65 type BINDING sequence D description BINDING => ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF source Swiss-Prot : SWS_FT_FI2 11) chain A residue 93 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P24289 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 65 type SITE sequence D description Important for catalytic activity => ECO:0000269|PubMed:28036383 source Swiss-Prot : SWS_FT_FI4 13) chain A residue 68 type SITE sequence K description Important for catalytic activity => ECO:0000250|UniProtKB:P24289 source Swiss-Prot : SWS_FT_FI5 14) chain A residue 112 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBD, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI6 15) chain A residue 122 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI7 16) chain A residue 248 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:28036383, ECO:0007744|PDB:5FB9, ECO:0007744|PDB:5FBA, ECO:0007744|PDB:5FBB, ECO:0007744|PDB:5FBC, ECO:0007744|PDB:5FBF, ECO:0007744|PDB:5FBG source Swiss-Prot : SWS_FT_FI8

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