eF-site ID 5f95-B PDB Code 5f95 Chain B click to enlarge Title Crystal structure of GSK3b in complex with Compound 18: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Glycogen synthase kinase-3 beta Source Homo sapiens (Human) (GSK3B_HUMAN) Sequence B:  KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKL CDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPV IYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV LKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT PTREQIREMNPNPWTKVFRPRTPPEAIALCSRLLEYTPTA RLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQEL SSNPPLATILIPPHARIQ Description Functional site 1) chain B residue 83 type sequence A description binding site for residue 3UP B 401 source : AC2 2) chain B residue 85 type sequence K description binding site for residue 3UP B 401 source : AC2 3) chain B residue 132 type sequence L description binding site for residue 3UP B 401 source : AC2 4) chain B residue 133 type sequence D description binding site for residue 3UP B 401 source : AC2 5) chain B residue 134 type sequence Y description binding site for residue 3UP B 401 source : AC2 6) chain B residue 135 type sequence V description binding site for residue 3UP B 401 source : AC2 7) chain B residue 188 type sequence L description binding site for residue 3UP B 401 source : AC2 8) chain B residue 199 type sequence C description binding site for residue 3UP B 401 source : AC2 9) chain B residue 200 type sequence D description binding site for residue 3UP B 401 source : AC2 10) chain B residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 11) chain B residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI4

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