eF-site ID 5f6l-A PDB Code 5f6l Chain A click to enlarge Title The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L Classification PROTEIN BINDING/TRANSFERASE Compound Retinoblastoma-binding protein 5 Source Homo sapiens (Human) (KMT2A_HUMAN) Sequence A:  LPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGE MVIEYAGIVIRSILTDKREKYYDSKGIGCYMFRIDDSEVV DATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRK IYRGEELTYDYKFPIEDKLPCNCGAKKCRKFLN Description Functional site 1) chain A residue 3838 type sequence I description binding site for residue SAH A 4001 source : AC1 2) chain A residue 3839 type sequence H description binding site for residue SAH A 4001 source : AC1 3) chain A residue 3840 type sequence G description binding site for residue SAH A 4001 source : AC1 4) chain A residue 3841 type sequence R description binding site for residue SAH A 4001 source : AC1 5) chain A residue 3903 type sequence R description binding site for residue SAH A 4001 source : AC1 6) chain A residue 3904 type sequence F description binding site for residue SAH A 4001 source : AC1 7) chain A residue 3906 type sequence N description binding site for residue SAH A 4001 source : AC1 8) chain A residue 3907 type sequence H description binding site for residue SAH A 4001 source : AC1 9) chain A residue 3944 type sequence Y description binding site for residue SAH A 4001 source : AC1 10) chain A residue 3956 type sequence P description binding site for residue SAH A 4001 source : AC1 11) chain A residue 3957 type sequence C description binding site for residue SAH A 4001 source : AC1 12) chain A residue 3958 type sequence N description binding site for residue SAH A 4001 source : AC1 13) chain A residue 3968 type sequence L description binding site for residue SAH A 4001 source : AC1 14) chain A residue 3909 type sequence C description binding site for residue ZN A 4002 source : AC2 15) chain A residue 3957 type sequence C description binding site for residue ZN A 4002 source : AC2 16) chain A residue 3959 type sequence C description binding site for residue ZN A 4002 source : AC2 17) chain A residue 3964 type sequence C description binding site for residue ZN A 4002 source : AC2 18) chain A residue 3883 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E source Swiss-Prot : SWS_FT_FI2 19) chain A residue 3909 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI4 20) chain A residue 3957 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI4 21) chain A residue 3959 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI4 22) chain A residue 3964 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI5 23) chain A residue 3839 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI1 24) chain A residue 3841 type BINDING sequence R description BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI1 25) chain A residue 3958 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI1 26) chain A residue 3882 type MOD_RES sequence C description S-methylcysteine; by autocatalysis => ECO:0000269|PubMed:24235145 source Swiss-Prot : SWS_FT_FI6 27) chain A residue 3906 type BINDING sequence N description BINDING => ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L source Swiss-Prot : SWS_FT_FI3

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