eF-site ID 5edd-A PDB Code 5edd Chain A click to enlarge Title Crystal structure of Mycobacterium tuberculosis dUTPase R140K, H145W mutant Classification HYDROLASE Compound Deoxyuridine 5'-triphosphate nucleotidohydrolase Source Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (DUT_MYCTA) Sequence A:  HSSGLVPRGSHMSTTLAIVRLDPGLPLPSRAHDGDAGVDL YSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLAT RVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGD RIAQLLVQRVELVELVEVSSFDEA Description Functional site 1) chain A residue 74 type sequence S description binding site for residue TRS A 201 source : AC1 2) chain A residue 74 type sequence S description binding site for residue TRS A 201 source : AC1 3) chain A residue 74 type sequence S description binding site for residue TRS A 201 source : AC1 4) chain A residue 75 type sequence I description binding site for residue TRS A 201 source : AC1 5) chain A residue 75 type sequence I description binding site for residue TRS A 201 source : AC1 6) chain A residue 75 type sequence I description binding site for residue TRS A 201 source : AC1 7) chain A residue 76 type sequence V description binding site for residue TRS A 201 source : AC1 8) chain A residue 76 type sequence V description binding site for residue TRS A 201 source : AC1 9) chain A residue 76 type sequence V description binding site for residue TRS A 201 source : AC1 10) chain A residue 64 type sequence R description binding site for residue DUP A 202 source : AC2 11) chain A residue 65 type sequence S description binding site for residue DUP A 202 source : AC2 12) chain A residue 66 type sequence G description binding site for residue DUP A 202 source : AC2 13) chain A residue 77 type sequence N description binding site for residue DUP A 202 source : AC2 14) chain A residue 80 type sequence G description binding site for residue DUP A 202 source : AC2 15) chain A residue 81 type sequence T description binding site for residue DUP A 202 source : AC2 16) chain A residue 82 type sequence I description binding site for residue DUP A 202 source : AC2 17) chain A residue 83 type sequence D description binding site for residue DUP A 202 source : AC2 18) chain A residue 86 type sequence Y description binding site for residue DUP A 202 source : AC2 19) chain A residue 89 type sequence E description binding site for residue DUP A 202 source : AC2 20) chain A residue 90 type sequence I description binding site for residue DUP A 202 source : AC2 21) chain A residue 91 type sequence K description binding site for residue DUP A 202 source : AC2 22) chain A residue 113 type sequence Q description binding site for residue DUP A 202 source : AC2 23) chain A residue 64 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00116, ECO:0000269|PubMed:15276840 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 77 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00116, ECO:0000269|PubMed:15276840 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 81 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00116, ECO:0000269|PubMed:15276840 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 91 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15276840 source Swiss-Prot : SWS_FT_FI2

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