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eF-site ID
|
5e8e-AHL |
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PDB Code
|
5e8e |
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Chain
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A, H, L |
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click to enlarge
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Title
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Crystal structure of thrombin bound to an exosite 1-specific IgA Fab |
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Classification
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IMMUNE SYSTEM/HYDROLASE |
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Compound
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IGA FAB LIGHT CHAIN |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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A: |
EIVLTQSPATLSLSPGERATLSCRASQNVSSFLAWYQHKP
GQAPRLLIYDASSRATDIPIRFSGSGSGTDFTLTISGLEP
EDFAVYYCQQRRSWPPLTFGGGTKVEIKRTVAAPSVFIFP
PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKQKVYACEVTHQ
GLSSPVTKSFLRGEC
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| H: |
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL
PDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVL
QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY
THVFRLKKWIQKVIDQFGE
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| L: |
TFGSGEADCGLRPLFEKKSLEDKTERELLESYI
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Description
|
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Functional site
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1)
|
chain |
H |
| residue |
359-364 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
|
|
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2)
|
chain |
H |
| residue |
519-530 |
| type |
prosite |
| sequence |
DACEGDSGGPFV
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
|
| source |
prosite : PS00135
|
|
|
3)
|
chain |
H |
| residue |
373 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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4)
|
chain |
A |
| residue |
193-199 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
|
|
|
5)
|
chain |
H |
| residue |
419 |
| type |
SITE |
| sequence |
D
|
| description |
Cleavage; by factor Xa => ECO:0000269|PubMed:34265300
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
H |
| residue |
525 |
| type |
SITE |
| sequence |
S
|
| description |
Cleavage; by factor Xa => ECO:0000269|PubMed:34265300
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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