eF-site/Summary 5e6w-A

eF-site ID	5e6w-A
PDB Code	5e6w
Chain	A

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Title	Re-refinement of the Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin b2 Subunit
Classification	CELL ADHESION
Compound	Integrin beta-2
Source	(ITB2_HUMAN)

Sequence	A:	QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRC DTRPQLLMRGCAADDIMDPTSLAETQEDQKQLSPQKVTLY LRPGQAAAFNVTFRRAKLSSRVFLDHNALPDTLKVTYDSF CSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQS FVIRALGFTDIVTVQVLPQCECRCRDQSRSLCHGKGFLEC GICRCDTGYIGKNCECQTQGRSQELEGSCRKDNNSIICSG LGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQV CGGPGRGLCFCGKCRCHPGFEGSACQHHHH

Description

Functional site


1)	chain	A
	residue	484-497
	type	prosite
	sequence	CSGLGDCVCGQCLC
	description	INTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsGl..GdCvCgqClC
	source	prosite : PS00243

2)	chain	A
	residue	527-542
	type	prosite
	sequence	CGGPGRGLCFCGKCRC
	description	INTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsGl..GdCvCgqClC
	source	prosite : PS00243

3)	chain	A
	residue	448-459
	type	prosite
	sequence	CRCDTGYIGKNC
	description	EGF_1 EGF-like domain signature 1. CrCdtGyiGKnC
	source	prosite : PS00022

4)	chain	A
	residue	540-551
	type	prosite
	sequence	CRCHPGFEGSAC
	description	EGF_1 EGF-like domain signature 1. CrCdtGyiGKnC
	source	prosite : PS00022

5)	chain	A
	residue	448-461
	type	prosite
	sequence	CRCDTGYIGKNCEC
	description	EGF_2 EGF-like domain signature 2. CrCdtGYigknce..C
	source	prosite : PS01186

6)	chain	A
	residue	540-551
	type	prosite
	sequence	CRCHPGFEGSAC
	description	EGF_2 EGF-like domain signature 2. CrCdtGYigknce..C
	source	prosite : PS01186

7)	chain	A
	residue	1
	type	MOD_RES
	sequence	Q
	description	Pyrrolidone carboxylic acid => ECO:0000305\|PubMed:2954816
	source	Swiss-Prot : SWS_FT_FI1

8)	chain	A
	residue	28
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19349973
	source	Swiss-Prot : SWS_FT_FI2

9)	chain	A
	residue	479
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000255
	source	Swiss-Prot : SWS_FT_FI4

10)	chain	A
	residue	94
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19349973, ECO:0000269\|PubMed:20033057, ECO:0000269\|PubMed:24385486, ECO:0007744\|PDB:4NEH, ECO:0007744\|PDB:4NEN
	source	Swiss-Prot : SWS_FT_FI3