|
eF-site ID
|
5e6u-B |
PDB Code
|
5e6u |
Chain
|
B |
|
click to enlarge
|
|
Title
|
Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand |
Classification
|
CELL ADHESION |
Compound
|
Integrin alpha-L |
Source
|
(ITB2_HUMAN) |
|
Sequence
|
B: |
QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRC
DTRPQLLMRGCAADDIMDPTSLAETQQKQLSPQKVTLYLR
PGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKK
LGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLR
NPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISG
NLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFH
FAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLA
HKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSED
SSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSN
GVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVI
RALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECG
ICRCDTGYIGKNC
|
|
Description
|
(1) |
Integrin alpha-L, Integrin beta-2
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
448-459 |
type |
prosite |
sequence |
CRCDTGYIGKNC
|
description |
EGF_1 EGF-like domain signature 1. CrCdtGyiGKnC
|
source |
prosite : PS00022
|
|
2)
|
chain |
B |
residue |
448-459 |
type |
prosite |
sequence |
CRCDTGYIGKNC
|
description |
EGF_2 EGF-like domain signature 2. CrCdtGYigkn....C
|
source |
prosite : PS01186
|
|
3)
|
chain |
B |
residue |
114 |
type |
BINDING |
sequence |
S
|
description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
B |
residue |
116 |
type |
BINDING |
sequence |
S
|
description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
5)
|
chain |
B |
residue |
212 |
type |
BINDING |
sequence |
E
|
description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
6)
|
chain |
B |
residue |
190 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
|
source |
Swiss-Prot : SWS_FT_FI10
|
|
7)
|
chain |
B |
residue |
232 |
type |
CARBOHYD |
sequence |
K
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
source |
Swiss-Prot : SWS_FT_FI11
|
|
8)
|
chain |
B |
residue |
119 |
type |
BINDING |
sequence |
D
|
description |
in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
9)
|
chain |
B |
residue |
120 |
type |
BINDING |
sequence |
D
|
description |
in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
10)
|
chain |
B |
residue |
151 |
type |
BINDING |
sequence |
D
|
description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
11)
|
chain |
B |
residue |
207 |
type |
BINDING |
sequence |
N
|
description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
12)
|
chain |
B |
residue |
209 |
type |
BINDING |
sequence |
D
|
description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
13)
|
chain |
B |
residue |
211 |
type |
BINDING |
sequence |
P
|
description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
14)
|
chain |
B |
residue |
242 |
type |
BINDING |
sequence |
D
|
description |
in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
15)
|
chain |
B |
residue |
325 |
type |
BINDING |
sequence |
E
|
description |
in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
16)
|
chain |
B |
residue |
1 |
type |
MOD_RES |
sequence |
Q
|
description |
Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
17)
|
chain |
B |
residue |
28 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
|
source |
Swiss-Prot : SWS_FT_FI8
|
|
18)
|
chain |
B |
residue |
94 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
source |
Swiss-Prot : SWS_FT_FI9
|
|
|
|