eF-site ID 5e6u-AB
PDB Code 5e6u
Chain A, B

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Title Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand
Classification CELL ADHESION
Compound Integrin alpha-L
Source (ITB2_HUMAN)
Sequence A:  YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGN
STGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTD
GSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRP
GFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKK
LSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVK
HMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDG
EATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASK
PASEFVKILDTFEKLKDLFTELQKKIQDLTSFNMELSSSG
ISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNE
PLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRV
LLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDG
ETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGD
PGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYI
FNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEG
DGLADVAVGAESQMIVLSSRPVV
B:  QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRC
DTRPQLLMRGCAADDIMDPTSLAETQQKQLSPQKVTLYLR
PGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKK
LGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLR
NPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISG
NLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDGFH
FAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLA
HKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSED
SSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSN
GVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVI
RALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECG
ICRCDTGYIGKNC
Description (1)  Integrin alpha-L, Integrin beta-2


Functional site
1) chain B
residue 448-459
type prosite
sequence CRCDTGYIGKNC
description EGF_1 EGF-like domain signature 1. CrCdtGyiGKnC
source prosite : PS00022
2) chain B
residue 448-459
type prosite
sequence CRCDTGYIGKNC
description EGF_2 EGF-like domain signature 2. CrCdtGYigkn....C
source prosite : PS01186
3) chain B
residue 114
type BINDING
sequence S
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 569
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
5) chain A
residue 573
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
6) chain B
residue 116
type BINDING
sequence S
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
7) chain B
residue 212
type BINDING
sequence E
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
8) chain A
residue 451
type BINDING
sequence E
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
9) chain A
residue 505
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
10) chain A
residue 507
type BINDING
sequence N
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
11) chain A
residue 509
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
12) chain A
residue 513
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
13) chain A
residue 565
type BINDING
sequence D
description in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI1
14) chain B
residue 190
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI10
15) chain B
residue 232
type CARBOHYD
sequence K
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI11
16) chain B
residue 119
type BINDING
sequence D
description in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
source Swiss-Prot : SWS_FT_FI2
17) chain A
residue 64
type BINDING
sequence N
description in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
source Swiss-Prot : SWS_FT_FI2
18) chain B
residue 120
type BINDING
sequence D
description in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI3
19) chain B
residue 151
type BINDING
sequence D
description in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI4
20) chain B
residue 207
type BINDING
sequence N
description in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI4
21) chain B
residue 209
type BINDING
sequence D
description in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI4
22) chain B
residue 211
type BINDING
sequence P
description in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI4
23) chain B
residue 242
type BINDING
sequence D
description in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI5
24) chain B
residue 325
type BINDING
sequence E
description in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH
source Swiss-Prot : SWS_FT_FI6
25) chain B
residue 1
type MOD_RES
sequence Q
description Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816
source Swiss-Prot : SWS_FT_FI7
26) chain B
residue 28
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
source Swiss-Prot : SWS_FT_FI8
27) chain B
residue 94
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
source Swiss-Prot : SWS_FT_FI9

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