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eF-site ID
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5e6u-A |
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PDB Code
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5e6u |
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Chain
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A |
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click to enlarge
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Title
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Structures of leukocyte integrin aLb2: The aI domain, the headpiece, and the pocket for the internal ligand |
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Classification
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CELL ADHESION |
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Compound
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Integrin alpha-L |
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Source
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(ITB2_HUMAN) |
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Sequence
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A: |
YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGN
STGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTD
GSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRP
GFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKK
LSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVK
HMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDG
EATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASK
PASEFVKILDTFEKLKDLFTELQKKIQDLTSFNMELSSSG
ISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNE
PLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRV
LLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDG
ETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGD
PGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYI
FNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEG
DGLADVAVGAESQMIVLSSRPVV
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Description
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(1) |
Integrin alpha-L, Integrin beta-2
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Functional site
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1)
|
chain |
A |
| residue |
569 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
|
chain |
A |
| residue |
573 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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3)
|
chain |
A |
| residue |
505 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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4)
|
chain |
A |
| residue |
507 |
| type |
BINDING |
| sequence |
N
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
509 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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6)
|
chain |
A |
| residue |
513 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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7)
|
chain |
A |
| residue |
565 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
451 |
| type |
BINDING |
| sequence |
E
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
A |
| residue |
64 |
| type |
BINDING |
| sequence |
N
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
|
| source |
Swiss-Prot : SWS_FT_FI2
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