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eF-site ID
|
5e6s-F |
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PDB Code
|
5e6s |
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Chain
|
F |
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click to enlarge
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Title
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Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand |
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Classification
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CELL ADHESION |
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Compound
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Integrin alpha-L |
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Source
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(ITB2_HUMAN) |
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Sequence
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F: |
QECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRC
DTRPQLLMRGCAADDIMDPTSLAETQEDQKQLSPQKVTLY
LRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNV
KKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDK
LRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLI
SGNLDAPEGGLDAMMQVAACPEEIGWRKVTRLLVFATDDG
FHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQ
LAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELS
EDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFC
SNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSF
VIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLE
CGICRCDTGYIGKNC
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Description
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(1) |
Integrin alpha-L, Integrin beta-2
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Functional site
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1)
|
chain |
F |
| residue |
190 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
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| source |
Swiss-Prot : SWS_FT_FI10
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2)
|
chain |
F |
| residue |
232 |
| type |
CARBOHYD |
| sequence |
K
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI11
|
|
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3)
|
chain |
F |
| residue |
1 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816
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| source |
Swiss-Prot : SWS_FT_FI7
|
|
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4)
|
chain |
F |
| residue |
28 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
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5)
|
chain |
F |
| residue |
94 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
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6)
|
chain |
F |
| residue |
325 |
| type |
BINDING |
| sequence |
E
|
| description |
in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH
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| source |
Swiss-Prot : SWS_FT_FI6
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7)
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chain |
F |
| residue |
120 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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8)
|
chain |
F |
| residue |
114 |
| type |
BINDING |
| sequence |
S
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
F |
| residue |
116 |
| type |
BINDING |
| sequence |
S
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
F |
| residue |
212 |
| type |
BINDING |
| sequence |
E
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
F |
| residue |
119 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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12)
|
chain |
F |
| residue |
151 |
| type |
BINDING |
| sequence |
D
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
13)
|
chain |
F |
| residue |
207 |
| type |
BINDING |
| sequence |
N
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
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14)
|
chain |
F |
| residue |
209 |
| type |
BINDING |
| sequence |
D
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
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15)
|
chain |
F |
| residue |
211 |
| type |
BINDING |
| sequence |
P
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI4
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|
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16)
|
chain |
F |
| residue |
242 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI5
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