|
|
eF-site ID
|
5e6s-E |
|
PDB Code
|
5e6s |
|
Chain
|
E |
|
click to enlarge
|
|
|
Title
|
Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand |
|
Classification
|
CELL ADHESION |
|
Compound
|
Integrin alpha-L |
|
Source
|
(ITB2_HUMAN) |
|
|
Sequence
|
E: |
YNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGN
STGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTD
GSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRP
GFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKK
LSNTSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVK
HMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDG
EATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASK
PASEFVKILDTFEKLKDLFTELQKKILTSFNMELSSSGIS
ADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPL
TPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLL
FQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGET
ELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPG
YPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFN
GRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDG
LADVAVGAESQMIVLSSRPV
|
|
|
Description
|
(1) |
Integrin alpha-L, Integrin beta-2
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
443 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
E |
| residue |
445 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
E |
| residue |
447 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
E |
| residue |
451 |
| type |
BINDING |
| sequence |
E
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
E |
| residue |
505 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
E |
| residue |
507 |
| type |
BINDING |
| sequence |
N
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
E |
| residue |
509 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
E |
| residue |
513 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
E |
| residue |
565 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
E |
| residue |
569 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
E |
| residue |
573 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
E |
| residue |
40 |
| type |
BINDING |
| sequence |
N
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
13)
|
chain |
E |
| residue |
64 |
| type |
BINDING |
| sequence |
N
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|