eF-site ID 5e3c-A PDB Code 5e3c Chain A click to enlarge Title Structure of human DPP3 in complex with hemorphin like opioid peptide IVYPW Classification HYDROLASE Compound Dipeptidyl peptidase 3 Source Homo sapiens (Human) (5E3C) Sequence A:  DTQYILPNDIGVSSLDSREAFRLLSPTERLYAYHLSRAAW YGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAE GLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEK LERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLG LGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFK EVDGCGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGS PFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYI ESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPF GSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPT FEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTE GFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPS FDVQVGLHALLGHGSGKLFVQDEKGAFNFDQETVINPETG EQIQSWYRCGETWDSKFSTIASSYEECRAESVGLYLSLHP QVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAF NWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDAR VRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYE GYATVTDAPPESFLTLRDTVLLRKESRKLIVQPNTRLEGS DVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATAD ARFW Description Functional site 1) chain A residue 450 type sequence H description binding site for residue ZN A 801 source : AC1 2) chain A residue 455 type sequence H description binding site for residue ZN A 801 source : AC1 3) chain A residue 508 type sequence E description binding site for residue ZN A 801 source : AC1 4) chain A residue 162 type sequence G description binding site for residue MG A 802 source : AC2 5) chain A residue 164 type sequence G description binding site for residue MG A 802 source : AC2 6) chain A residue 167 type sequence G description binding site for residue MG A 802 source : AC2 7) chain A residue 317 type sequence S description binding site for residue K A 803 source : AC3 8) chain A residue 323 type sequence G description binding site for residue K A 803 source : AC3 9) chain A residue 496 type sequence D description binding site for residue K A 803 source : AC3 10) chain A residue 504 type sequence S description binding site for residue K A 803 source : AC3 11) chain A residue 101 type sequence S description binding site for residue MG A 804 source : AC4 12) chain A residue 102 type sequence N description binding site for residue MG A 804 source : AC4 13) chain A residue 108 type sequence S description binding site for residue MG A 804 source : AC4 14) chain A residue 384 type sequence S description binding site for residue MG A 804 source : AC4 15) chain A residue 451 type ACT_SITE sequence A description ACT_SITE => ECO:0000250|UniProtKB:O55096 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 450 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22493238, ECO:0007744|PDB:3FVY source Swiss-Prot : SWS_FT_FI2 17) chain A residue 455 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22493238, ECO:0007744|PDB:3FVY source Swiss-Prot : SWS_FT_FI2 18) chain A residue 508 type BINDING sequence E description BINDING => ECO:0000269|PubMed:22493238, ECO:0007744|PDB:3FVY source Swiss-Prot : SWS_FT_FI2

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