eF-site ID 5e26-D PDB Code 5e26 Chain D click to enlarge Title Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate Classification TRANSFERASE Compound Pantothenate kinase 2, mitochondrial Source Homo sapiens (Human) (PANK2_HUMAN) Sequence D:  RPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLKS IRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRF PTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFLT IGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPA DSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKR VTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVD KLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSKE DLARATLITITNNIGSIARMCALNENINQVVFVGNFLRIN TIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELL Description Functional site 1) chain D residue 469 type sequence A description binding site for residue PAU C 602 source : AC8 2) chain D residue 338 type sequence E description binding site for residue PAU D 601 source : AC9 3) chain D residue 393 type sequence G description binding site for residue PAU D 601 source : AC9 4) chain D residue 394 type sequence V description binding site for residue PAU D 601 source : AC9 5) chain D residue 395 type sequence S description binding site for residue PAU D 601 source : AC9 6) chain D residue 407 type sequence R description binding site for residue PAU D 601 source : AC9 7) chain D residue 410 type sequence G description binding site for residue PAU D 601 source : AC9 8) chain D residue 411 type sequence T description binding site for residue PAU D 601 source : AC9 9) chain D residue 412 type sequence S description binding site for residue PAU D 601 source : AC9 10) chain D residue 219 type sequence G description binding site for residue ADP D 602 source : AD1 11) chain D residue 220 type sequence G description binding site for residue ADP D 602 source : AD1 12) chain D residue 221 type sequence T description binding site for residue ADP D 602 source : AD1 13) chain D residue 222 type sequence L description binding site for residue ADP D 602 source : AD1 14) chain D residue 224 type sequence K description binding site for residue ADP D 602 source : AD1 15) chain D residue 391 type sequence G description binding site for residue ADP D 602 source : AD1 16) chain D residue 392 type sequence S description binding site for residue ADP D 602 source : AD1 17) chain D residue 415 type sequence G description binding site for residue ADP D 602 source : AD1 18) chain D residue 416 type sequence G description binding site for residue ADP D 602 source : AD1 19) chain D residue 431 type sequence F description binding site for residue ADP D 602 source : AD1 20) chain D residue 522 type sequence N description binding site for residue ADP D 602 source : AD1 21) chain D residue 523 type sequence F description binding site for residue ADP D 602 source : AD1 22) chain D residue 525 type sequence R description binding site for residue ADP D 602 source : AD1 23) chain D residue 350 type sequence D description binding site for residue GOL D 603 source : AD2 24) chain D residue 378 type sequence D description binding site for residue GOL D 603 source : AD2 25) chain D residue 379 type sequence L description binding site for residue GOL D 603 source : AD2 26) chain D residue 549 type sequence L description binding site for residue GOL D 603 source : AD2 27) chain D residue 227 type sequence Y description binding site for residue CL D 604 source : AD3 28) chain D residue 249 type sequence R description binding site for residue CL D 604 source : AD3 29) chain D residue 338 type ACT_SITE sequence E description Proton acceptor => ECO:0000250|UniProtKB:Q9H999 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 392 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 31) chain D residue 395 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 32) chain D residue 407 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2

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