eF-site ID 5e26-ABCD
PDB Code 5e26
Chain A, B, C, D

click to enlarge
Title Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
Classification TRANSFERASE
Compound Pantothenate kinase 2, mitochondrial
Source Homo sapiens (Human) (PANK2_HUMAN)
Sequence A:  RPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLKS
IRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRF
PTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFLT
IGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPA
DSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKR
VTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVD
KLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSKE
DLARATLITITNNIGSIARMCALNENINQVVFVGNFLRIN
TIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELL
B:  KRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLK
SIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIR
FPTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFL
TIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENP
ADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYK
RVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKV
DKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSK
EDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRI
NTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLEL
LK
C:  KRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLK
SIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIR
FPTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFL
TIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENP
ADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYK
RVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKV
DKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSK
EDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRI
NTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLEL
L
D:  RPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLKS
IRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRF
PTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFLT
IGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPA
DSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKR
VTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVD
KLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSKE
DLARATLITITNNIGSIARMCALNENINQVVFVGNFLRIN
TIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELL
Description


Functional site

1) chain A
residue 219
type
sequence G
description binding site for residue ADP A 601
source : AC1

2) chain A
residue 220
type
sequence G
description binding site for residue ADP A 601
source : AC1

3) chain A
residue 221
type
sequence T
description binding site for residue ADP A 601
source : AC1

4) chain A
residue 222
type
sequence L
description binding site for residue ADP A 601
source : AC1

5) chain A
residue 224
type
sequence K
description binding site for residue ADP A 601
source : AC1

6) chain A
residue 286
type
sequence R
description binding site for residue ADP A 601
source : AC1

7) chain A
residue 391
type
sequence G
description binding site for residue ADP A 601
source : AC1

8) chain A
residue 392
type
sequence S
description binding site for residue ADP A 601
source : AC1

9) chain A
residue 415
type
sequence G
description binding site for residue ADP A 601
source : AC1

10) chain A
residue 416
type
sequence G
description binding site for residue ADP A 601
source : AC1

11) chain A
residue 419
type
sequence F
description binding site for residue ADP A 601
source : AC1

12) chain A
residue 431
type
sequence F
description binding site for residue ADP A 601
source : AC1

13) chain A
residue 432
type
sequence E
description binding site for residue ADP A 601
source : AC1

14) chain A
residue 522
type
sequence N
description binding site for residue ADP A 601
source : AC1

15) chain A
residue 523
type
sequence F
description binding site for residue ADP A 601
source : AC1

16) chain A
residue 525
type
sequence R
description binding site for residue ADP A 601
source : AC1

17) chain A
residue 338
type
sequence E
description binding site for residue PAU A 602
source : AC2

18) chain A
residue 393
type
sequence G
description binding site for residue PAU A 602
source : AC2

19) chain A
residue 394
type
sequence V
description binding site for residue PAU A 602
source : AC2

20) chain A
residue 395
type
sequence S
description binding site for residue PAU A 602
source : AC2

21) chain A
residue 407
type
sequence R
description binding site for residue PAU A 602
source : AC2

22) chain A
residue 410
type
sequence G
description binding site for residue PAU A 602
source : AC2

23) chain A
residue 411
type
sequence T
description binding site for residue PAU A 602
source : AC2

24) chain B
residue 469
type
sequence A
description binding site for residue PAU A 602
source : AC2

25) chain A
residue 477
type
sequence S
description binding site for residue GOL A 603
source : AC3

26) chain A
residue 478
type
sequence K
description binding site for residue GOL A 603
source : AC3

27) chain A
residue 479
type
sequence E
description binding site for residue GOL A 603
source : AC3

28) chain B
residue 290
type
sequence H
description binding site for residue GOL A 603
source : AC3

29) chain A
residue 469
type
sequence A
description binding site for residue PAU B 601
source : AC4

30) chain B
residue 338
type
sequence E
description binding site for residue PAU B 601
source : AC4

31) chain B
residue 393
type
sequence G
description binding site for residue PAU B 601
source : AC4

32) chain B
residue 394
type
sequence V
description binding site for residue PAU B 601
source : AC4

33) chain B
residue 395
type
sequence S
description binding site for residue PAU B 601
source : AC4

34) chain B
residue 407
type
sequence R
description binding site for residue PAU B 601
source : AC4

35) chain B
residue 410
type
sequence G
description binding site for residue PAU B 601
source : AC4

36) chain B
residue 411
type
sequence T
description binding site for residue PAU B 601
source : AC4

37) chain B
residue 219
type
sequence G
description binding site for residue ADP B 602
source : AC5

38) chain B
residue 220
type
sequence G
description binding site for residue ADP B 602
source : AC5

39) chain B
residue 221
type
sequence T
description binding site for residue ADP B 602
source : AC5

40) chain B
residue 222
type
sequence L
description binding site for residue ADP B 602
source : AC5

41) chain B
residue 224
type
sequence K
description binding site for residue ADP B 602
source : AC5

42) chain B
residue 286
type
sequence R
description binding site for residue ADP B 602
source : AC5

43) chain B
residue 391
type
sequence G
description binding site for residue ADP B 602
source : AC5

44) chain B
residue 392
type
sequence S
description binding site for residue ADP B 602
source : AC5

45) chain B
residue 415
type
sequence G
description binding site for residue ADP B 602
source : AC5

46) chain B
residue 416
type
sequence G
description binding site for residue ADP B 602
source : AC5

47) chain B
residue 419
type
sequence F
description binding site for residue ADP B 602
source : AC5

48) chain B
residue 431
type
sequence F
description binding site for residue ADP B 602
source : AC5

49) chain B
residue 521
type
sequence G
description binding site for residue ADP B 602
source : AC5

50) chain B
residue 522
type
sequence N
description binding site for residue ADP B 602
source : AC5

51) chain B
residue 523
type
sequence F
description binding site for residue ADP B 602
source : AC5

52) chain B
residue 525
type
sequence R
description binding site for residue ADP B 602
source : AC5

53) chain B
residue 227
type
sequence Y
description binding site for residue CL B 603
source : AC6

54) chain B
residue 230
type
sequence P
description binding site for residue CL B 603
source : AC6

55) chain B
residue 249
type
sequence R
description binding site for residue CL B 603
source : AC6

56) chain C
residue 219
type
sequence G
description binding site for residue ADP C 601
source : AC7

57) chain C
residue 220
type
sequence G
description binding site for residue ADP C 601
source : AC7

58) chain C
residue 221
type
sequence T
description binding site for residue ADP C 601
source : AC7

59) chain C
residue 222
type
sequence L
description binding site for residue ADP C 601
source : AC7

60) chain C
residue 224
type
sequence K
description binding site for residue ADP C 601
source : AC7

61) chain C
residue 391
type
sequence G
description binding site for residue ADP C 601
source : AC7

62) chain C
residue 392
type
sequence S
description binding site for residue ADP C 601
source : AC7

63) chain C
residue 415
type
sequence G
description binding site for residue ADP C 601
source : AC7

64) chain C
residue 416
type
sequence G
description binding site for residue ADP C 601
source : AC7

65) chain C
residue 431
type
sequence F
description binding site for residue ADP C 601
source : AC7

66) chain C
residue 432
type
sequence E
description binding site for residue ADP C 601
source : AC7

67) chain C
residue 522
type
sequence N
description binding site for residue ADP C 601
source : AC7

68) chain C
residue 523
type
sequence F
description binding site for residue ADP C 601
source : AC7

69) chain C
residue 525
type
sequence R
description binding site for residue ADP C 601
source : AC7

70) chain C
residue 338
type
sequence E
description binding site for residue PAU C 602
source : AC8

71) chain C
residue 393
type
sequence G
description binding site for residue PAU C 602
source : AC8

72) chain C
residue 394
type
sequence V
description binding site for residue PAU C 602
source : AC8

73) chain C
residue 395
type
sequence S
description binding site for residue PAU C 602
source : AC8

74) chain C
residue 407
type
sequence R
description binding site for residue PAU C 602
source : AC8

75) chain C
residue 410
type
sequence G
description binding site for residue PAU C 602
source : AC8

76) chain C
residue 411
type
sequence T
description binding site for residue PAU C 602
source : AC8

77) chain D
residue 469
type
sequence A
description binding site for residue PAU C 602
source : AC8

78) chain C
residue 469
type
sequence A
description binding site for residue PAU D 601
source : AC9

79) chain D
residue 338
type
sequence E
description binding site for residue PAU D 601
source : AC9

80) chain D
residue 393
type
sequence G
description binding site for residue PAU D 601
source : AC9

81) chain D
residue 394
type
sequence V
description binding site for residue PAU D 601
source : AC9

82) chain D
residue 395
type
sequence S
description binding site for residue PAU D 601
source : AC9

83) chain D
residue 407
type
sequence R
description binding site for residue PAU D 601
source : AC9

84) chain D
residue 410
type
sequence G
description binding site for residue PAU D 601
source : AC9

85) chain D
residue 411
type
sequence T
description binding site for residue PAU D 601
source : AC9

86) chain D
residue 412
type
sequence S
description binding site for residue PAU D 601
source : AC9

87) chain D
residue 219
type
sequence G
description binding site for residue ADP D 602
source : AD1

88) chain D
residue 220
type
sequence G
description binding site for residue ADP D 602
source : AD1

89) chain D
residue 221
type
sequence T
description binding site for residue ADP D 602
source : AD1

90) chain D
residue 222
type
sequence L
description binding site for residue ADP D 602
source : AD1

91) chain D
residue 224
type
sequence K
description binding site for residue ADP D 602
source : AD1

92) chain D
residue 391
type
sequence G
description binding site for residue ADP D 602
source : AD1

93) chain D
residue 392
type
sequence S
description binding site for residue ADP D 602
source : AD1

94) chain D
residue 415
type
sequence G
description binding site for residue ADP D 602
source : AD1

95) chain D
residue 416
type
sequence G
description binding site for residue ADP D 602
source : AD1

96) chain D
residue 431
type
sequence F
description binding site for residue ADP D 602
source : AD1

97) chain D
residue 522
type
sequence N
description binding site for residue ADP D 602
source : AD1

98) chain D
residue 523
type
sequence F
description binding site for residue ADP D 602
source : AD1

99) chain D
residue 525
type
sequence R
description binding site for residue ADP D 602
source : AD1

100) chain D
residue 350
type
sequence D
description binding site for residue GOL D 603
source : AD2

101) chain D
residue 378
type
sequence D
description binding site for residue GOL D 603
source : AD2

102) chain D
residue 379
type
sequence L
description binding site for residue GOL D 603
source : AD2

103) chain D
residue 549
type
sequence L
description binding site for residue GOL D 603
source : AD2

104) chain D
residue 227
type
sequence Y
description binding site for residue CL D 604
source : AD3

105) chain D
residue 249
type
sequence R
description binding site for residue CL D 604
source : AD3

106) chain A
residue 392
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

107) chain D
residue 392
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

108) chain D
residue 395
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

109) chain D
residue 407
type BINDING
sequence R
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

110) chain A
residue 395
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

111) chain A
residue 407
type BINDING
sequence R
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

112) chain B
residue 392
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

113) chain B
residue 395
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

114) chain B
residue 407
type BINDING
sequence R
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

115) chain C
residue 392
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

116) chain C
residue 395
type BINDING
sequence S
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

117) chain C
residue 407
type BINDING
sequence R
description BINDING => ECO:0000250|UniProtKB:Q8TE04
source Swiss-Prot : SWS_FT_FI2

118) chain A
residue 338
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000250|UniProtKB:Q9H999
source Swiss-Prot : SWS_FT_FI1

119) chain B
residue 338
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000250|UniProtKB:Q9H999
source Swiss-Prot : SWS_FT_FI1

120) chain C
residue 338
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000250|UniProtKB:Q9H999
source Swiss-Prot : SWS_FT_FI1

121) chain D
residue 338
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000250|UniProtKB:Q9H999
source Swiss-Prot : SWS_FT_FI1


Display surface

Download
Links