eF-site ID 5e26-C PDB Code 5e26 Chain C click to enlarge Title Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate Classification TRANSFERASE Compound Pantothenate kinase 2, mitochondrial Source Homo sapiens (Human) (PANK2_HUMAN) Sequence C:  KRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLK SIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIR FPTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFL TIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENP ADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYK RVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKV DKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSK EDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRI NTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLEL L Description Functional site 1) chain C residue 219 type sequence G description binding site for residue ADP C 601 source : AC7 2) chain C residue 220 type sequence G description binding site for residue ADP C 601 source : AC7 3) chain C residue 221 type sequence T description binding site for residue ADP C 601 source : AC7 4) chain C residue 222 type sequence L description binding site for residue ADP C 601 source : AC7 5) chain C residue 224 type sequence K description binding site for residue ADP C 601 source : AC7 6) chain C residue 391 type sequence G description binding site for residue ADP C 601 source : AC7 7) chain C residue 392 type sequence S description binding site for residue ADP C 601 source : AC7 8) chain C residue 415 type sequence G description binding site for residue ADP C 601 source : AC7 9) chain C residue 416 type sequence G description binding site for residue ADP C 601 source : AC7 10) chain C residue 431 type sequence F description binding site for residue ADP C 601 source : AC7 11) chain C residue 432 type sequence E description binding site for residue ADP C 601 source : AC7 12) chain C residue 522 type sequence N description binding site for residue ADP C 601 source : AC7 13) chain C residue 523 type sequence F description binding site for residue ADP C 601 source : AC7 14) chain C residue 525 type sequence R description binding site for residue ADP C 601 source : AC7 15) chain C residue 338 type sequence E description binding site for residue PAU C 602 source : AC8 16) chain C residue 393 type sequence G description binding site for residue PAU C 602 source : AC8 17) chain C residue 394 type sequence V description binding site for residue PAU C 602 source : AC8 18) chain C residue 395 type sequence S description binding site for residue PAU C 602 source : AC8 19) chain C residue 407 type sequence R description binding site for residue PAU C 602 source : AC8 20) chain C residue 410 type sequence G description binding site for residue PAU C 602 source : AC8 21) chain C residue 411 type sequence T description binding site for residue PAU C 602 source : AC8 22) chain C residue 469 type sequence A description binding site for residue PAU D 601 source : AC9 23) chain C residue 338 type ACT_SITE sequence E description Proton acceptor => ECO:0000250|UniProtKB:Q9H999 source Swiss-Prot : SWS_FT_FI1 24) chain C residue 392 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 25) chain C residue 395 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 26) chain C residue 407 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2

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