eF-site ID 5e26-B PDB Code 5e26 Chain B click to enlarge Title Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate Classification TRANSFERASE Compound Pantothenate kinase 2, mitochondrial Source Homo sapiens (Human) (PANK2_HUMAN) Sequence B:  KRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLK SIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIR FPTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFL TIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENP ADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYK RVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKV DKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSK EDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRI NTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLEL LK Description Functional site 1) chain B residue 469 type sequence A description binding site for residue PAU A 602 source : AC2 2) chain B residue 290 type sequence H description binding site for residue GOL A 603 source : AC3 3) chain B residue 338 type sequence E description binding site for residue PAU B 601 source : AC4 4) chain B residue 393 type sequence G description binding site for residue PAU B 601 source : AC4 5) chain B residue 394 type sequence V description binding site for residue PAU B 601 source : AC4 6) chain B residue 395 type sequence S description binding site for residue PAU B 601 source : AC4 7) chain B residue 407 type sequence R description binding site for residue PAU B 601 source : AC4 8) chain B residue 410 type sequence G description binding site for residue PAU B 601 source : AC4 9) chain B residue 411 type sequence T description binding site for residue PAU B 601 source : AC4 10) chain B residue 219 type sequence G description binding site for residue ADP B 602 source : AC5 11) chain B residue 220 type sequence G description binding site for residue ADP B 602 source : AC5 12) chain B residue 221 type sequence T description binding site for residue ADP B 602 source : AC5 13) chain B residue 222 type sequence L description binding site for residue ADP B 602 source : AC5 14) chain B residue 224 type sequence K description binding site for residue ADP B 602 source : AC5 15) chain B residue 286 type sequence R description binding site for residue ADP B 602 source : AC5 16) chain B residue 391 type sequence G description binding site for residue ADP B 602 source : AC5 17) chain B residue 392 type sequence S description binding site for residue ADP B 602 source : AC5 18) chain B residue 415 type sequence G description binding site for residue ADP B 602 source : AC5 19) chain B residue 416 type sequence G description binding site for residue ADP B 602 source : AC5 20) chain B residue 419 type sequence F description binding site for residue ADP B 602 source : AC5 21) chain B residue 431 type sequence F description binding site for residue ADP B 602 source : AC5 22) chain B residue 521 type sequence G description binding site for residue ADP B 602 source : AC5 23) chain B residue 522 type sequence N description binding site for residue ADP B 602 source : AC5 24) chain B residue 523 type sequence F description binding site for residue ADP B 602 source : AC5 25) chain B residue 525 type sequence R description binding site for residue ADP B 602 source : AC5 26) chain B residue 227 type sequence Y description binding site for residue CL B 603 source : AC6 27) chain B residue 230 type sequence P description binding site for residue CL B 603 source : AC6 28) chain B residue 249 type sequence R description binding site for residue CL B 603 source : AC6 29) chain B residue 338 type ACT_SITE sequence E description Proton acceptor => ECO:0000250|UniProtKB:Q9H999 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 392 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 395 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 407 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2

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