eF-site ID 5e26-A PDB Code 5e26 Chain A click to enlarge Title Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate Classification TRANSFERASE Compound Pantothenate kinase 2, mitochondrial Source Homo sapiens (Human) (PANK2_HUMAN) Sequence A:  RPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLKS IRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRF PTHDMPAFIQMGRDKNFSSLHTVFCATGGGAYKFEQDFLT IGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPA DSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKR VTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVD KLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSKE DLARATLITITNNIGSIARMCALNENINQVVFVGNFLRIN TIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELL Description Functional site 1) chain A residue 219 type sequence G description binding site for residue ADP A 601 source : AC1 2) chain A residue 220 type sequence G description binding site for residue ADP A 601 source : AC1 3) chain A residue 221 type sequence T description binding site for residue ADP A 601 source : AC1 4) chain A residue 222 type sequence L description binding site for residue ADP A 601 source : AC1 5) chain A residue 224 type sequence K description binding site for residue ADP A 601 source : AC1 6) chain A residue 286 type sequence R description binding site for residue ADP A 601 source : AC1 7) chain A residue 391 type sequence G description binding site for residue ADP A 601 source : AC1 8) chain A residue 392 type sequence S description binding site for residue ADP A 601 source : AC1 9) chain A residue 415 type sequence G description binding site for residue ADP A 601 source : AC1 10) chain A residue 416 type sequence G description binding site for residue ADP A 601 source : AC1 11) chain A residue 419 type sequence F description binding site for residue ADP A 601 source : AC1 12) chain A residue 431 type sequence F description binding site for residue ADP A 601 source : AC1 13) chain A residue 432 type sequence E description binding site for residue ADP A 601 source : AC1 14) chain A residue 522 type sequence N description binding site for residue ADP A 601 source : AC1 15) chain A residue 523 type sequence F description binding site for residue ADP A 601 source : AC1 16) chain A residue 525 type sequence R description binding site for residue ADP A 601 source : AC1 17) chain A residue 338 type sequence E description binding site for residue PAU A 602 source : AC2 18) chain A residue 393 type sequence G description binding site for residue PAU A 602 source : AC2 19) chain A residue 394 type sequence V description binding site for residue PAU A 602 source : AC2 20) chain A residue 395 type sequence S description binding site for residue PAU A 602 source : AC2 21) chain A residue 407 type sequence R description binding site for residue PAU A 602 source : AC2 22) chain A residue 410 type sequence G description binding site for residue PAU A 602 source : AC2 23) chain A residue 411 type sequence T description binding site for residue PAU A 602 source : AC2 24) chain A residue 477 type sequence S description binding site for residue GOL A 603 source : AC3 25) chain A residue 478 type sequence K description binding site for residue GOL A 603 source : AC3 26) chain A residue 479 type sequence E description binding site for residue GOL A 603 source : AC3 27) chain A residue 469 type sequence A description binding site for residue PAU B 601 source : AC4 28) chain A residue 392 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 395 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 407 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q8TE04 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 338 type ACT_SITE sequence E description Proton acceptor => ECO:0000250|UniProtKB:Q9H999 source Swiss-Prot : SWS_FT_FI1

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