eF-site ID 5e0u-ABCDEF
PDB Code 5e0u
Chain A, B, C, D, E, F

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Title Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms
Classification DNA BINDING PROTEIN
Compound Proliferating cell nuclear antigen
Source Homo sapiens (Human) (CDN1A_HUMAN)
Sequence A:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM
DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK
CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI
SCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMN
EPVQLTFALRYLNFFTKATPLSSTVTLIMSADVPLVVEYK
IADMGHLKYYLAPKI
B:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM
DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK
CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI
SCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMN
EPVQLTFALRYLNFFTKATPLSSTVTLIMSADVPLVVEYK
IADMGHLKYYLAPKI
C:  MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSM
DSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILK
CAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVI
SCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMN
EPVQLTFALRYLNFFTKATPLSSTVTLIMSADVPLVVEYK
IADMGHLKYYLAPKI
D:  RQTSMTDFYHSKRRLIFS
E:  RRQTSMTDFYHSKRRLIFS
F:  RQTSMTDFYHSKRRLIFS
Description


Functional site
1) chain D
residue 145
type MOD_RES
sequence T
description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683
source Swiss-Prot : SWS_FT_FI1
2) chain E
residue 145
type MOD_RES
sequence T
description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683
source Swiss-Prot : SWS_FT_FI1
3) chain F
residue 145
type MOD_RES
sequence T
description Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:20307683
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 61-79
type prosite
sequence RCDRNLAMGVNLTSMSKIL
description PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL
source prosite : PS00293
5) chain A
residue 34-57
type prosite
sequence GVNLQSMDSSHVSLVQLTLRSEGF
description PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF
source prosite : PS01251
6) chain A
residue 254
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI6
7) chain B
residue 254
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI6
8) chain C
residue 254
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI6
9) chain D
residue 146
type MOD_RES
sequence S
description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316
source Swiss-Prot : SWS_FT_FI2
10) chain E
residue 146
type MOD_RES
sequence S
description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316
source Swiss-Prot : SWS_FT_FI2
11) chain F
residue 146
type MOD_RES
sequence S
description Phosphoserine; by PKC and NUAK1 => ECO:0000269|PubMed:10753973, ECO:0000269|PubMed:25329316
source Swiss-Prot : SWS_FT_FI2
12) chain D
residue 160
type MOD_RES
sequence S
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
13) chain E
residue 160
type MOD_RES
sequence S
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
14) chain F
residue 160
type MOD_RES
sequence S
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
15) chain B
residue 77
type MOD_RES
sequence K
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
16) chain B
residue 80
type MOD_RES
sequence K
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
17) chain B
residue 248
type MOD_RES
sequence K
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
18) chain C
residue 77
type MOD_RES
sequence K
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
19) chain C
residue 80
type MOD_RES
sequence K
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
20) chain C
residue 248
type MOD_RES
sequence K
description Phosphoserine; by PKC; in vitro => ECO:0000269|PubMed:10753973
source Swiss-Prot : SWS_FT_FI3
21) chain A
residue 211
type MOD_RES
sequence Y
description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032
source Swiss-Prot : SWS_FT_FI4
22) chain B
residue 211
type MOD_RES
sequence Y
description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032
source Swiss-Prot : SWS_FT_FI4
23) chain C
residue 211
type MOD_RES
sequence Y
description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:17115032
source Swiss-Prot : SWS_FT_FI4
24) chain A
residue 164
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289
source Swiss-Prot : SWS_FT_FI5
25) chain B
residue 164
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289
source Swiss-Prot : SWS_FT_FI5
26) chain C
residue 164
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289
source Swiss-Prot : SWS_FT_FI5

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