eF-site ID 5dv4-A
PDB Code 5dv4
Chain A

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Title Crystal structure of human CNOT6L in complex with neomycin
Classification HYDROLASE
Compound CCR4-NOT transcription complex subunit 6-like
Source (CNO6L_HUMAN)
Sequence A:  LPPRPWITLKERDQSASFTVMCYNVLCDKYATRQLYGYCP
SWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFL
PALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEK
FTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVV
LEVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEV
KNILEKASSRPNSIPLVLCADLNSLPDSGVVEYLSNGGVA
DNHKDFKELRYNECLMNFSCEGRITHGFQLKSAYENNLMP
YTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENN
ITGCPHPHIPSDHFSLLTQLELHP
Description


Functional site

1) chain A
residue 206
type
sequence L
description binding site for residue NMY A 601
source : AC1

2) chain A
residue 207
type
sequence Y
description binding site for residue NMY A 601
source : AC1

3) chain A
residue 240
type
sequence E
description binding site for residue NMY A 601
source : AC1

4) chain A
residue 360
type
sequence H
description binding site for residue NMY A 601
source : AC1

5) chain A
residue 361
type
sequence M
description binding site for residue NMY A 601
source : AC1

6) chain A
residue 363
type
sequence W
description binding site for residue NMY A 601
source : AC1

7) chain A
residue 365
type
sequence P
description binding site for residue NMY A 601
source : AC1

8) chain A
residue 371
type
sequence K
description binding site for residue NMY A 601
source : AC1

9) chain A
residue 410
type
sequence D
description binding site for residue NMY A 601
source : AC1

10) chain A
residue 412
type
sequence N
description binding site for residue NMY A 601
source : AC1

11) chain A
residue 414
type
sequence L
description binding site for residue NMY A 601
source : AC1

12) chain A
residue 479
type
sequence N
description binding site for residue NMY A 601
source : AC1

13) chain A
residue 484
type
sequence F
description binding site for residue NMY A 601
source : AC1

14) chain A
residue 488
type
sequence I
description binding site for residue NMY A 601
source : AC1

15) chain A
residue 201
type
sequence Y
description binding site for residue SO4 A 602
source : AC2

16) chain A
residue 363
type
sequence W
description binding site for residue SO4 A 602
source : AC2

17) chain A
residue 243
type
sequence T
description binding site for residue SO4 A 603
source : AC3

18) chain A
residue 244
type
sequence E
description binding site for residue SO4 A 603
source : AC3

19) chain A
residue 278
type
sequence K
description binding site for residue SO4 A 603
source : AC3

20) chain A
residue 410
type ACT_SITE
sequence D
description Proton donor/acceptor => ECO:0000305|PubMed:20628353, ECO:0000305|PubMed:27013054
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 240
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 360
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 412
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 479
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 276
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGN
source Swiss-Prot : SWS_FT_FI3

26) chain A
residue 365
type BINDING
sequence P
description BINDING => ECO:0000269|PubMed:20628353
source Swiss-Prot : SWS_FT_FI4

27) chain A
residue 410
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGQ
source Swiss-Prot : SWS_FT_FI5

28) chain A
residue 484
type BINDING
sequence F
description BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:5DV2
source Swiss-Prot : SWS_FT_FI6


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