eF-site ID 5dne-D PDB Code 5dne Chain D click to enlarge Title Crystal structure of the Asn-bound guinea pig L-asparaginase 1 catalytic domain active site mutant K188M Classification HYDROLASE Compound L-asparaginase Source Cavia porcellus (Guinea pig) (H0W0T5_CAVPO) Sequence D:  ERHLLLIYTGGTLGMQSKGGVLVPGPGLVTLLRTLPMFHD KEFAQAQGLPDHALALPPASHGPRVLYTVLECQPLLDSSD MTIDDWIRIAKIIERHYEQYQGFVVIHGTDTMASGASMLS FMLENLHKPVILTGAQVPIRVLWNDARENLLGALLVAGQY IIPEVCLFMNSQLFRGNRVTMVDSQKFEAFCSPNLSPLAT VGADVTIAWDLVRKVKWKDPLVVHSNMEHDVALLRLYPGI PASLVRAFLQPPLKGVVLETFGSGNGPSKPDLLQELRAAA QRGLIMVNCSQCLRGSVTPGYATSLAGANIVSGLDMTSEA ALAKLSYVLGLPELSLERRQELLAKDLRGEMTLPTA Description Functional site 1) chain D residue 207 type sequence T description binding site for residue EDO C 603 source : AC9 2) chain D residue 208 type sequence V description binding site for residue EDO C 603 source : AC9 3) chain D residue 209 type sequence G description binding site for residue EDO C 603 source : AC9 4) chain D residue 193 type sequence K description binding site for residue EDO C 605 source : AD2 5) chain D residue 194 type sequence F description binding site for residue EDO C 605 source : AD2 6) chain D residue 195 type sequence E description binding site for residue EDO C 605 source : AD2 7) chain D residue 18 type sequence G description binding site for residue ASN D 601 source : AD3 8) chain D residue 19 type sequence T description binding site for residue ASN D 601 source : AD3 9) chain D residue 22 type sequence M description binding site for residue ASN D 601 source : AD3 10) chain D residue 84 type sequence D description binding site for residue ASN D 601 source : AD3 11) chain D residue 85 type sequence S description binding site for residue ASN D 601 source : AD3 12) chain D residue 115 type sequence G description binding site for residue ASN D 601 source : AD3 13) chain D residue 116 type sequence T description binding site for residue ASN D 601 source : AD3 14) chain D residue 117 type sequence D description binding site for residue ASN D 601 source : AD3 15) chain D residue 142 type sequence A description binding site for residue ASN D 601 source : AD3 16) chain D residue 143 type sequence Q description binding site for residue ASN D 601 source : AD3 17) chain D residue 201 type sequence N description binding site for residue EDO D 602 source : AD4 18) chain D residue 297 type sequence S description binding site for residue EDO D 602 source : AD4 19) chain D residue 299 type sequence C description binding site for residue EDO D 602 source : AD4 20) chain D residue 300 type sequence L description binding site for residue EDO D 602 source : AD4 21) chain D residue 302 type sequence G description binding site for residue EDO D 602 source : AD4 22) chain D residue 323 type sequence M description binding site for residue EDO D 602 source : AD4

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