eF-site ID 5dne-B PDB Code 5dne Chain B click to enlarge Title Crystal structure of the Asn-bound guinea pig L-asparaginase 1 catalytic domain active site mutant K188M Classification HYDROLASE Compound L-asparaginase Source Cavia porcellus (Guinea pig) (H0W0T5_CAVPO) Sequence B:  SERHLLLIYTGGTLGMQSKGGVLVPGPGLVTLLRTLPMFH DKEFAQAQGLPDHALALPPASHGPRVLYTVLECQPLLDSS DMTIDDWIRIAKIIERHYEQYQGFVVIHGTDTMASGASML SFMLENLHKPVILTGAQVPIRVLWNDARENLLGALLVAGQ YIIPEVCLFMNSQLFRGNRVTMVDSQKFEAFCSPNLSPLA TVGADVTIAWDLVRKVKWKDPLVVHSNMEHDVALLRLYPG IPASLVRAFLQPPLKGVVLETFGSGNGPSKPDLLQELRAA AQRGLIMVNCSQCLRGSVTPGYATSLAGANIVSGLDMTSE AALAKLSYVLGLPELSLERRQELLAKDLRGEMTLPT Description Functional site 1) chain B residue 150 type sequence W description binding site for residue EDO A 602 source : AC2 2) chain B residue 193 type sequence K description binding site for residue EDO A 603 source : AC3 3) chain B residue 194 type sequence F description binding site for residue EDO A 603 source : AC3 4) chain B residue 195 type sequence E description binding site for residue EDO A 603 source : AC3 5) chain B residue 18 type sequence G description binding site for residue ASN B 601 source : AC4 6) chain B residue 19 type sequence T description binding site for residue ASN B 601 source : AC4 7) chain B residue 84 type sequence D description binding site for residue ASN B 601 source : AC4 8) chain B residue 85 type sequence S description binding site for residue ASN B 601 source : AC4 9) chain B residue 115 type sequence G description binding site for residue ASN B 601 source : AC4 10) chain B residue 116 type sequence T description binding site for residue ASN B 601 source : AC4 11) chain B residue 117 type sequence D description binding site for residue ASN B 601 source : AC4 12) chain B residue 142 type sequence A description binding site for residue ASN B 601 source : AC4 13) chain B residue 143 type sequence Q description binding site for residue ASN B 601 source : AC4 14) chain B residue 151 type sequence N description binding site for residue EDO B 602 source : AC5 15) chain B residue 152 type sequence D description binding site for residue EDO B 602 source : AC5 16) chain B residue 297 type sequence S description binding site for residue EDO B 603 source : AC6 17) chain B residue 299 type sequence C description binding site for residue EDO B 603 source : AC6 18) chain B residue 323 type sequence M description binding site for residue EDO B 603 source : AC6 19) chain B residue 324 type sequence T description binding site for residue EDO B 603 source : AC6 20) chain B residue 325 type sequence S description binding site for residue EDO B 603 source : AC6 21) chain B residue 308 type sequence Y description binding site for residue ASN C 601 source : AC7

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