eF-site ID 5dne-A PDB Code 5dne Chain A click to enlarge Title Crystal structure of the Asn-bound guinea pig L-asparaginase 1 catalytic domain active site mutant K188M Classification HYDROLASE Compound L-asparaginase Source Cavia porcellus (Guinea pig) (H0W0T5_CAVPO) Sequence A:  ERHLLLIYTGGTLGMQSKGGVLVPGPGLVTLLRTLPMFHD KEFAQAQGLPDHALALPPASHGPRVLYTVLECQPLLDSSD MTIDDWIRIAKIIERHYEQYQGFVVIHGTDTMASGASMLS FMLENLHKPVILTGAQVPIRVLWNDARENLLGALLVAGQY IIPEVCLFMNSQLFRGNRVTMVDSQKFEAFCSPNLSPLAT VGADVTIAWDLVRKVKWKDPLVVHSNMEHDVALLRLYPGI PASLVRAFLQPPLKGVVLETFGSGNGPSKPDLLQELRAAA QRGLIMVNCSQCLRGSVTPGYATSLAGANIVSGLDMTSEA ALAKLSYVLGLPELSLERRQELLAKDLRGEMTLP Description Functional site 1) chain A residue 18 type sequence G description binding site for residue ASN A 601 source : AC1 2) chain A residue 19 type sequence T description binding site for residue ASN A 601 source : AC1 3) chain A residue 22 type sequence M description binding site for residue ASN A 601 source : AC1 4) chain A residue 84 type sequence D description binding site for residue ASN A 601 source : AC1 5) chain A residue 85 type sequence S description binding site for residue ASN A 601 source : AC1 6) chain A residue 115 type sequence G description binding site for residue ASN A 601 source : AC1 7) chain A residue 116 type sequence T description binding site for residue ASN A 601 source : AC1 8) chain A residue 117 type sequence D description binding site for residue ASN A 601 source : AC1 9) chain A residue 142 type sequence A description binding site for residue ASN A 601 source : AC1 10) chain A residue 143 type sequence Q description binding site for residue ASN A 601 source : AC1 11) chain A residue 209 type sequence G description binding site for residue EDO A 602 source : AC2 12) chain A residue 210 type sequence A description binding site for residue EDO A 602 source : AC2 13) chain A residue 211 type sequence D description binding site for residue EDO A 602 source : AC2 14) chain A residue 212 type sequence V description binding site for residue EDO A 602 source : AC2 15) chain A residue 178 type sequence S description binding site for residue EDO A 603 source : AC3 16) chain A residue 208 type sequence V description binding site for residue EDO A 603 source : AC3 17) chain A residue 209 type sequence G description binding site for residue EDO A 603 source : AC3 18) chain A residue 178 type sequence S description binding site for residue EDO B 602 source : AC5 19) chain A residue 308 type sequence Y description binding site for residue ASN D 601 source : AD3 20) chain A residue 109-119 type prosite sequence GFVVIHGTDTM description ASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GfVviHGTDTM source prosite : PS00917

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