eF-site ID 5dkh-ABC PDB Code 5dkh Chain A, B, C click to enlarge Title Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17 Classification TRANSCRIPTION Compound Probable global transcription activator SNF2L2 Source Homo sapiens (Human) (SMCA2_HUMAN) Sequence A:  SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRK ELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLL CHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEE B:  PKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPE YYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNA QTFNLEGSQIYEDSIVLQSVFKSARQKIAK C:  PPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELP EYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHN AQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEE Description Functional site 1) chain A residue 1441 type sequence H description binding site for residue ZN A 1501 source : AC1 2) chain A residue 1458 type sequence H description binding site for residue ZN A 1501 source : AC1 3) chain A residue 1439 type sequence R description binding site for residue ZN A 1502 source : AC2 4) chain A residue 1441 type sequence H description binding site for residue ZN A 1502 source : AC2 5) chain A residue 1458 type sequence H description binding site for residue ZN A 1502 source : AC2 6) chain A residue 1408 type sequence V description binding site for residue 5C0 A 1503 source : AC3 7) chain A residue 1409 type sequence F description binding site for residue 5C0 A 1503 source : AC3 8) chain A residue 1412 type sequence L description binding site for residue 5C0 A 1503 source : AC3 9) chain A residue 1417 type sequence E description binding site for residue 5C0 A 1503 source : AC3 10) chain A residue 1418 type sequence L description binding site for residue 5C0 A 1503 source : AC3 11) chain A residue 1421 type sequence Y description binding site for residue 5C0 A 1503 source : AC3 12) chain A residue 1429 type sequence V description binding site for residue 5C0 A 1503 source : AC3 13) chain A residue 1459 type sequence N description binding site for residue 5C0 A 1503 source : AC3 14) chain A residue 1460 type sequence A description binding site for residue 5C0 A 1503 source : AC3 15) chain A residue 1464 type sequence N description binding site for residue 5C0 A 1503 source : AC3 16) chain A residue 1470 type sequence I description binding site for residue 5C0 A 1503 source : AC3 17) chain B residue 1441 type sequence H description binding site for residue ZN B 1501 source : AC4 18) chain B residue 1458 type sequence H description binding site for residue ZN B 1501 source : AC4 19) chain B residue 1441 type sequence H description binding site for residue ZN B 1502 source : AC5 20) chain B residue 1458 type sequence H description binding site for residue ZN B 1502 source : AC5 21) chain B residue 1467 type sequence G description binding site for residue EDO B 1503 source : AC6 22) chain B residue 1472 type sequence E description binding site for residue EDO B 1503 source : AC6 23) chain C residue 1417 type sequence E description binding site for residue EDO B 1503 source : AC6 24) chain A residue 1382 type sequence K description binding site for residue EDO B 1504 source : AC7 25) chain B residue 1417 type sequence E description binding site for residue EDO B 1504 source : AC7 26) chain C residue 1490 type sequence K description binding site for residue EDO B 1504 source : AC7 27) chain C residue 1491 type sequence E description binding site for residue EDO B 1504 source : AC7 28) chain A residue 1489 type sequence A description binding site for residue 5C0 B 1505 source : AC8 29) chain B residue 1408 type sequence V description binding site for residue 5C0 B 1505 source : AC8 30) chain B residue 1409 type sequence F description binding site for residue 5C0 B 1505 source : AC8 31) chain B residue 1412 type sequence L description binding site for residue 5C0 B 1505 source : AC8 32) chain B residue 1421 type sequence Y description binding site for residue 5C0 B 1505 source : AC8 33) chain B residue 1429 type sequence V description binding site for residue 5C0 B 1505 source : AC8 34) chain B residue 1460 type sequence A description binding site for residue 5C0 B 1505 source : AC8 35) chain B residue 1464 type sequence N description binding site for residue 5C0 B 1505 source : AC8 36) chain B residue 1470 type sequence I description binding site for residue 5C0 B 1505 source : AC8 37) chain C residue 1441 type sequence H description binding site for residue ZN C 1501 source : AC9 38) chain C residue 1458 type sequence H description binding site for residue ZN C 1501 source : AC9 39) chain C residue 1441 type sequence H description binding site for residue ZN C 1502 source : AD1 40) chain C residue 1458 type sequence H description binding site for residue ZN C 1502 source : AD1 41) chain A residue 1406-1463 type prosite sequence SEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRS LGDLEKDVMLLCHNAQTF description BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslgdlekdvml.LchNAqtF source prosite : PS00633 42) chain A residue 1377 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI1

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