eF-site ID 5dir-A PDB Code 5dir Chain A click to enlarge Title membrane protein at 2.8 Angstroms Classification HYDROLASE Compound Lipoprotein signal peptidase Source (5DIR) Sequence A:  PDVDRFGRLPWLWITVLVFVLDQVSKAFFQAELSMYQQIV VIPDLFSWTLAYNTGAAFSFLADSSGWQRWLFALIAIVVS ASLVVWLKRLKKGETWLAIALALVLGGALGNLYDRMVLGH VVDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMF Description Functional site 1) chain A residue 100 type sequence I description binding site for residue OLC A 201 source : AC1 2) chain A residue 139 type sequence F description binding site for residue OLC A 201 source : AC1 3) chain A residue 143 type sequence D description binding site for residue OLC A 201 source : AC1 4) chain A residue 147 type sequence T description binding site for residue OLC A 201 source : AC1 5) chain A residue 148 type sequence V description binding site for residue OLC A 201 source : AC1 6) chain A residue 26 type sequence S description binding site for residue OLC A 202 source : AC2 7) chain A residue 29 type sequence F description binding site for residue OLC A 202 source : AC2 8) chain A residue 33 type sequence E description binding site for residue OLC A 202 source : AC2 9) chain A residue 40 type sequence I description binding site for residue OLC A 202 source : AC2 10) chain A residue 49 type sequence W description binding site for residue OLC A 202 source : AC2 11) chain A residue 141 type sequence L description binding site for residue OLC A 202 source : AC2 12) chain A residue 41 type sequence V description binding site for residue OLC A 203 source : AC3 13) chain A residue 49 type sequence W description binding site for residue OLC A 203 source : AC3 14) chain A residue 4 type sequence V description binding site for residue OLC A 204 source : AC4 15) chain A residue 8 type sequence G description binding site for residue OLC A 204 source : AC4 16) chain A residue 11 type sequence P description binding site for residue OLC A 204 source : AC4 17) chain A residue 12 type sequence W description binding site for residue OLC A 204 source : AC4 18) chain A residue 15 type sequence I description binding site for residue OLC A 204 source : AC4 19) chain A residue 93 type sequence K description binding site for residue OLC A 204 source : AC4 20) chain A residue 10 type sequence L description binding site for residue OLC A 205 source : AC5 21) chain A residue 11 type sequence P description binding site for residue OLC A 205 source : AC5 22) chain A residue 14 type sequence W description binding site for residue OLC A 205 source : AC5 23) chain A residue 20 type sequence F description binding site for residue OLC A 205 source : AC5 24) chain A residue 20 type sequence F description binding site for residue OLC A 206 source : AC6 25) chain A residue 70 type sequence R description binding site for residue OLC A 206 source : AC6 26) chain A residue 117 type sequence M description binding site for residue OLC A 206 source : AC6 27) chain A residue 63 type sequence A description binding site for residue OLC B 206 source : AD3 28) chain A residue 64 type sequence D description binding site for residue OLC B 206 source : AD3 29) chain A residue 65 type sequence S description binding site for residue OLC B 206 source : AD3 30) chain A residue 71 type sequence W description binding site for residue OLC B 206 source : AD3 31) chain A residue 54 type sequence N description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 32) chain A residue 59 type sequence F description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 33) chain A residue 62 type sequence L description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 34) chain A residue 72 type sequence L description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 35) chain A residue 73 type sequence F description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 36) chain A residue 112 type sequence N description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 37) chain A residue 116 type sequence R description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 38) chain A residue 122 type sequence V description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 39) chain A residue 124 type sequence D description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 40) chain A residue 140 type sequence N description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 41) chain A residue 143 type sequence D description binding site for Ligand residues ALO E 204 through SER E 203 bound to SER E 203 source : AE7 42) chain A residue 105-117 type prosite sequence VLGGALGNLYDRM description SPASE_II Signal peptidases II signature. VlGGALGNLYDRM source prosite : PS00855 43) chain A residue 31-67 type TOPO_DOM sequence QAELSMYQQIVVIPDLFSWTLAYNTGAAFSFLADSSG description Periplasmic => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS source Swiss-Prot : SWS_FT_FI3 44) chain A residue 119-140 type TOPO_DOM sequence LGHVVDFILVHWQNRWYFPAFN description Periplasmic => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS source Swiss-Prot : SWS_FT_FI3 45) chain A residue 68-89 type TRANSMEM sequence WQRWLFALIAIVVSASLVVWLK description Helical => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS source Swiss-Prot : SWS_FT_FI4 46) chain A residue 97-118 type TRANSMEM sequence WLAIALALVLGGALGNLYDRMV description Helical => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS source Swiss-Prot : SWS_FT_FI4 47) chain A residue 141-154 type TRANSMEM sequence LADSAITVGAVMLA description Helical => ECO:0000269|PubMed:26912896, ECO:0007744|PDB:5DIR source Swiss-Prot : SWS_FT_FI5 48) chain A residue 124 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00161, ECO:0000305|PubMed:26912896 source Swiss-Prot : SWS_FT_FI7 49) chain A residue 143 type ACT_SITE sequence D description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00161, ECO:0000305|PubMed:26912896 source Swiss-Prot : SWS_FT_FI7 50) chain A residue 90-96 type TOPO_DOM sequence RLKKGET description Cytoplasmic => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS source Swiss-Prot : SWS_FT_FI1 51) chain A residue 10-30 type TRANSMEM sequence LPWLWITVLVFVLDQVSKAFF description Helical => ECO:0000255|HAMAP-Rule:MF_00161, ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS source Swiss-Prot : SWS_FT_FI2

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