eF-site ID 5ddy-ACEG
PDB Code 5ddy
Chain A, C, E, G

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Title Binary complex of human Polymerase lambda with dCTP
Classification TRANSFERASE
Compound DNA polymerase lambda
Source Homo sapiens (Human) (DPOLL_HUMAN)
Sequence A:  ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKS
FHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHI
SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQAS
LTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS
GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL
DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR
LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS
EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYR
EPAERDW
C:  ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKS
FHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHI
SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQAS
LTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS
GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL
DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR
LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS
EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYR
EPAERDW
E:  VPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTT
QQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLL
CVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSL
RQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDI
IVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHA
LSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPA
ERDW
G:  VPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTT
QQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLL
CVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSL
RQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDI
IVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHA
LSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPA
ERDW
Description


Functional site

1) chain A
residue 416
type
sequence G
description binding site for residue MG A 601
source : AC1

2) chain A
residue 417
type
sequence S
description binding site for residue MG A 601
source : AC1

3) chain A
residue 427
type
sequence D
description binding site for residue MG A 601
source : AC1

4) chain A
residue 429
type
sequence D
description binding site for residue MG A 601
source : AC1

5) chain A
residue 427
type
sequence D
description binding site for residue MN A 602
source : AC2

6) chain A
residue 429
type
sequence D
description binding site for residue MN A 602
source : AC2

7) chain A
residue 490
type
sequence D
description binding site for residue MN A 602
source : AC2

8) chain A
residue 386
type
sequence R
description binding site for residue DCP A 603
source : AC3

9) chain A
residue 416
type
sequence G
description binding site for residue DCP A 603
source : AC3

10) chain A
residue 417
type
sequence S
description binding site for residue DCP A 603
source : AC3

11) chain A
residue 420
type
sequence R
description binding site for residue DCP A 603
source : AC3

12) chain A
residue 426
type
sequence G
description binding site for residue DCP A 603
source : AC3

13) chain A
residue 427
type
sequence D
description binding site for residue DCP A 603
source : AC3

14) chain A
residue 429
type
sequence D
description binding site for residue DCP A 603
source : AC3

15) chain A
residue 505
type
sequence Y
description binding site for residue DCP A 603
source : AC3

16) chain A
residue 506
type
sequence F
description binding site for residue DCP A 603
source : AC3

17) chain A
residue 507
type
sequence T
description binding site for residue DCP A 603
source : AC3

18) chain A
residue 508
type
sequence G
description binding site for residue DCP A 603
source : AC3

19) chain A
residue 513
type
sequence N
description binding site for residue DCP A 603
source : AC3

20) chain A
residue 339
type
sequence S
description binding site for residue MN A 604
source : AC4

21) chain A
residue 341
type
sequence I
description binding site for residue MN A 604
source : AC4

22) chain A
residue 344
type
sequence A
description binding site for residue MN A 604
source : AC4

23) chain C
residue 416
type
sequence G
description binding site for residue MG C 601
source : AC5

24) chain C
residue 417
type
sequence S
description binding site for residue MG C 601
source : AC5

25) chain C
residue 427
type
sequence D
description binding site for residue MG C 601
source : AC5

26) chain C
residue 429
type
sequence D
description binding site for residue MG C 601
source : AC5

27) chain C
residue 427
type
sequence D
description binding site for residue MN C 602
source : AC6

28) chain C
residue 429
type
sequence D
description binding site for residue MN C 602
source : AC6

29) chain C
residue 490
type
sequence D
description binding site for residue MN C 602
source : AC6

30) chain C
residue 386
type
sequence R
description binding site for residue DCP C 603
source : AC7

31) chain C
residue 416
type
sequence G
description binding site for residue DCP C 603
source : AC7

32) chain C
residue 417
type
sequence S
description binding site for residue DCP C 603
source : AC7

33) chain C
residue 420
type
sequence R
description binding site for residue DCP C 603
source : AC7

34) chain C
residue 426
type
sequence G
description binding site for residue DCP C 603
source : AC7

35) chain C
residue 427
type
sequence D
description binding site for residue DCP C 603
source : AC7

36) chain C
residue 429
type
sequence D
description binding site for residue DCP C 603
source : AC7

37) chain C
residue 505
type
sequence Y
description binding site for residue DCP C 603
source : AC7

38) chain C
residue 506
type
sequence F
description binding site for residue DCP C 603
source : AC7

39) chain C
residue 508
type
sequence G
description binding site for residue DCP C 603
source : AC7

40) chain C
residue 513
type
sequence N
description binding site for residue DCP C 603
source : AC7

41) chain C
residue 339
type
sequence S
description binding site for residue MN C 604
source : AC8

42) chain E
residue 416
type
sequence G
description binding site for residue MG E 601
source : AC9

43) chain E
residue 417
type
sequence S
description binding site for residue MG E 601
source : AC9

44) chain E
residue 427
type
sequence D
description binding site for residue MG E 601
source : AC9

45) chain E
residue 429
type
sequence D
description binding site for residue MG E 601
source : AC9

46) chain E
residue 427
type
sequence D
description binding site for residue MN E 602
source : AD1

47) chain E
residue 429
type
sequence D
description binding site for residue MN E 602
source : AD1

48) chain E
residue 490
type
sequence D
description binding site for residue MN E 602
source : AD1

49) chain E
residue 386
type
sequence R
description binding site for residue DCP E 603
source : AD2

50) chain E
residue 417
type
sequence S
description binding site for residue DCP E 603
source : AD2

51) chain E
residue 420
type
sequence R
description binding site for residue DCP E 603
source : AD2

52) chain E
residue 426
type
sequence G
description binding site for residue DCP E 603
source : AD2

53) chain E
residue 427
type
sequence D
description binding site for residue DCP E 603
source : AD2

54) chain E
residue 429
type
sequence D
description binding site for residue DCP E 603
source : AD2

55) chain E
residue 505
type
sequence Y
description binding site for residue DCP E 603
source : AD2

56) chain E
residue 506
type
sequence F
description binding site for residue DCP E 603
source : AD2

57) chain E
residue 508
type
sequence G
description binding site for residue DCP E 603
source : AD2

58) chain E
residue 339
type
sequence S
description binding site for residue MN E 604
source : AD3

59) chain E
residue 341
type
sequence I
description binding site for residue MN E 604
source : AD3

60) chain G
residue 416
type
sequence G
description binding site for residue MG G 601
source : AD4

61) chain G
residue 417
type
sequence S
description binding site for residue MG G 601
source : AD4

62) chain G
residue 427
type
sequence D
description binding site for residue MG G 601
source : AD4

63) chain G
residue 429
type
sequence D
description binding site for residue MG G 601
source : AD4

64) chain G
residue 427
type
sequence D
description binding site for residue MN G 602
source : AD5

65) chain G
residue 429
type
sequence D
description binding site for residue MN G 602
source : AD5

66) chain G
residue 490
type
sequence D
description binding site for residue MN G 602
source : AD5

67) chain G
residue 386
type
sequence R
description binding site for residue DCP G 603
source : AD6

68) chain G
residue 417
type
sequence S
description binding site for residue DCP G 603
source : AD6

69) chain G
residue 420
type
sequence R
description binding site for residue DCP G 603
source : AD6

70) chain G
residue 426
type
sequence G
description binding site for residue DCP G 603
source : AD6

71) chain G
residue 427
type
sequence D
description binding site for residue DCP G 603
source : AD6

72) chain G
residue 429
type
sequence D
description binding site for residue DCP G 603
source : AD6

73) chain G
residue 505
type
sequence Y
description binding site for residue DCP G 603
source : AD6

74) chain G
residue 506
type
sequence F
description binding site for residue DCP G 603
source : AD6

75) chain G
residue 507
type
sequence T
description binding site for residue DCP G 603
source : AD6

76) chain G
residue 508
type
sequence G
description binding site for residue DCP G 603
source : AD6

77) chain G
residue 513
type
sequence N
description binding site for residue DCP G 603
source : AD6

78) chain G
residue 339
type
sequence S
description binding site for residue MN G 604
source : AD7

79) chain G
residue 341
type
sequence I
description binding site for residue MN G 604
source : AD7

80) chain G
residue 344
type
sequence A
description binding site for residue MN G 604
source : AD7

81) chain A
residue 416-435
type prosite
sequence GSYRRGKATCGDVDVLITHP
description DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP
source prosite : PS00522

82) chain A
residue 312
type ACT_SITE
sequence K
description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865
source Swiss-Prot : SWS_FT_FI1

83) chain C
residue 312
type ACT_SITE
sequence K
description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865
source Swiss-Prot : SWS_FT_FI1

84) chain A
residue 386
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

85) chain E
residue 417
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

86) chain E
residue 426
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

87) chain E
residue 513
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

88) chain G
residue 386
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

89) chain G
residue 417
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

90) chain G
residue 426
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

91) chain G
residue 513
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

92) chain A
residue 417
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

93) chain A
residue 426
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

94) chain A
residue 513
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

95) chain C
residue 386
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

96) chain C
residue 417
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

97) chain C
residue 426
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

98) chain C
residue 513
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

99) chain E
residue 386
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI2

100) chain A
residue 427
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

101) chain G
residue 427
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

102) chain G
residue 429
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

103) chain G
residue 490
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

104) chain A
residue 429
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

105) chain A
residue 490
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

106) chain C
residue 427
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

107) chain C
residue 429
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

108) chain C
residue 490
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

109) chain E
residue 427
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

110) chain E
residue 429
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3

111) chain E
residue 490
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
source Swiss-Prot : SWS_FT_FI3


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