eF-site ID 5ddy-ACEG PDB Code 5ddy Chain A, C, E, G click to enlarge Title Binary complex of human Polymerase lambda with dCTP Classification TRANSFERASE Compound DNA polymerase lambda Source Homo sapiens (Human) (DPOLL_HUMAN) Sequence A:  ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKS FHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHI SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQAS LTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYR EPAERDW C:  ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKS FHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHI SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQAS LTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYR EPAERDW E:  VPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTT QQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLL CVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSL RQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDI IVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHA LSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPA ERDW G:  VPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTT QQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLL CVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSL RQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDI IVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHA LSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPA ERDW Description Functional site 1) chain A residue 416 type sequence G description binding site for residue MG A 601 source : AC1 2) chain A residue 417 type sequence S description binding site for residue MG A 601 source : AC1 3) chain A residue 427 type sequence D description binding site for residue MG A 601 source : AC1 4) chain A residue 429 type sequence D description binding site for residue MG A 601 source : AC1 5) chain A residue 427 type sequence D description binding site for residue MN A 602 source : AC2 6) chain A residue 429 type sequence D description binding site for residue MN A 602 source : AC2 7) chain A residue 490 type sequence D description binding site for residue MN A 602 source : AC2 8) chain A residue 386 type sequence R description binding site for residue DCP A 603 source : AC3 9) chain A residue 416 type sequence G description binding site for residue DCP A 603 source : AC3 10) chain A residue 417 type sequence S description binding site for residue DCP A 603 source : AC3 11) chain A residue 420 type sequence R description binding site for residue DCP A 603 source : AC3 12) chain A residue 426 type sequence G description binding site for residue DCP A 603 source : AC3 13) chain A residue 427 type sequence D description binding site for residue DCP A 603 source : AC3 14) chain A residue 429 type sequence D description binding site for residue DCP A 603 source : AC3 15) chain A residue 505 type sequence Y description binding site for residue DCP A 603 source : AC3 16) chain A residue 506 type sequence F description binding site for residue DCP A 603 source : AC3 17) chain A residue 507 type sequence T description binding site for residue DCP A 603 source : AC3 18) chain A residue 508 type sequence G description binding site for residue DCP A 603 source : AC3 19) chain A residue 513 type sequence N description binding site for residue DCP A 603 source : AC3 20) chain A residue 339 type sequence S description binding site for residue MN A 604 source : AC4 21) chain A residue 341 type sequence I description binding site for residue MN A 604 source : AC4 22) chain A residue 344 type sequence A description binding site for residue MN A 604 source : AC4 23) chain C residue 416 type sequence G description binding site for residue MG C 601 source : AC5 24) chain C residue 417 type sequence S description binding site for residue MG C 601 source : AC5 25) chain C residue 427 type sequence D description binding site for residue MG C 601 source : AC5 26) chain C residue 429 type sequence D description binding site for residue MG C 601 source : AC5 27) chain C residue 427 type sequence D description binding site for residue MN C 602 source : AC6 28) chain C residue 429 type sequence D description binding site for residue MN C 602 source : AC6 29) chain C residue 490 type sequence D description binding site for residue MN C 602 source : AC6 30) chain C residue 386 type sequence R description binding site for residue DCP C 603 source : AC7 31) chain C residue 416 type sequence G description binding site for residue DCP C 603 source : AC7 32) chain C residue 417 type sequence S description binding site for residue DCP C 603 source : AC7 33) chain C residue 420 type sequence R description binding site for residue DCP C 603 source : AC7 34) chain C residue 426 type sequence G description binding site for residue DCP C 603 source : AC7 35) chain C residue 427 type sequence D description binding site for residue DCP C 603 source : AC7 36) chain C residue 429 type sequence D description binding site for residue DCP C 603 source : AC7 37) chain C residue 505 type sequence Y description binding site for residue DCP C 603 source : AC7 38) chain C residue 506 type sequence F description binding site for residue DCP C 603 source : AC7 39) chain C residue 508 type sequence G description binding site for residue DCP C 603 source : AC7 40) chain C residue 513 type sequence N description binding site for residue DCP C 603 source : AC7 41) chain C residue 339 type sequence S description binding site for residue MN C 604 source : AC8 42) chain E residue 416 type sequence G description binding site for residue MG E 601 source : AC9 43) chain E residue 417 type sequence S description binding site for residue MG E 601 source : AC9 44) chain E residue 427 type sequence D description binding site for residue MG E 601 source : AC9 45) chain E residue 429 type sequence D description binding site for residue MG E 601 source : AC9 46) chain E residue 427 type sequence D description binding site for residue MN E 602 source : AD1 47) chain E residue 429 type sequence D description binding site for residue MN E 602 source : AD1 48) chain E residue 490 type sequence D description binding site for residue MN E 602 source : AD1 49) chain E residue 386 type sequence R description binding site for residue DCP E 603 source : AD2 50) chain E residue 417 type sequence S description binding site for residue DCP E 603 source : AD2 51) chain E residue 420 type sequence R description binding site for residue DCP E 603 source : AD2 52) chain E residue 426 type sequence G description binding site for residue DCP E 603 source : AD2 53) chain E residue 427 type sequence D description binding site for residue DCP E 603 source : AD2 54) chain E residue 429 type sequence D description binding site for residue DCP E 603 source : AD2 55) chain E residue 505 type sequence Y description binding site for residue DCP E 603 source : AD2 56) chain E residue 506 type sequence F description binding site for residue DCP E 603 source : AD2 57) chain E residue 508 type sequence G description binding site for residue DCP E 603 source : AD2 58) chain E residue 339 type sequence S description binding site for residue MN E 604 source : AD3 59) chain E residue 341 type sequence I description binding site for residue MN E 604 source : AD3 60) chain G residue 416 type sequence G description binding site for residue MG G 601 source : AD4 61) chain G residue 417 type sequence S description binding site for residue MG G 601 source : AD4 62) chain G residue 427 type sequence D description binding site for residue MG G 601 source : AD4 63) chain G residue 429 type sequence D description binding site for residue MG G 601 source : AD4 64) chain G residue 427 type sequence D description binding site for residue MN G 602 source : AD5 65) chain G residue 429 type sequence D description binding site for residue MN G 602 source : AD5 66) chain G residue 490 type sequence D description binding site for residue MN G 602 source : AD5 67) chain G residue 386 type sequence R description binding site for residue DCP G 603 source : AD6 68) chain G residue 417 type sequence S description binding site for residue DCP G 603 source : AD6 69) chain G residue 420 type sequence R description binding site for residue DCP G 603 source : AD6 70) chain G residue 426 type sequence G description binding site for residue DCP G 603 source : AD6 71) chain G residue 427 type sequence D description binding site for residue DCP G 603 source : AD6 72) chain G residue 429 type sequence D description binding site for residue DCP G 603 source : AD6 73) chain G residue 505 type sequence Y description binding site for residue DCP G 603 source : AD6 74) chain G residue 506 type sequence F description binding site for residue DCP G 603 source : AD6 75) chain G residue 507 type sequence T description binding site for residue DCP G 603 source : AD6 76) chain G residue 508 type sequence G description binding site for residue DCP G 603 source : AD6 77) chain G residue 513 type sequence N description binding site for residue DCP G 603 source : AD6 78) chain G residue 339 type sequence S description binding site for residue MN G 604 source : AD7 79) chain G residue 341 type sequence I description binding site for residue MN G 604 source : AD7 80) chain G residue 344 type sequence A description binding site for residue MN G 604 source : AD7 81) chain A residue 416-435 type prosite sequence GSYRRGKATCGDVDVLITHP description DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP source prosite : PS00522 82) chain A residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 83) chain C residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 84) chain A residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 85) chain E residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 86) chain E residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 87) chain E residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 88) chain G residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 89) chain G residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 90) chain G residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 91) chain G residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 92) chain A residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 93) chain A residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 94) chain A residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 95) chain C residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 96) chain C residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 97) chain C residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 98) chain C residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 99) chain E residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 100) chain A residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 101) chain G residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 102) chain G residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 103) chain G residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 104) chain A residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 105) chain A residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 106) chain C residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 107) chain C residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 108) chain C residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 109) chain E residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 110) chain E residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 111) chain E residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3

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