eF-site ID 5ddy-A PDB Code 5ddy Chain A click to enlarge Title Binary complex of human Polymerase lambda with dCTP Classification TRANSFERASE Compound DNA polymerase lambda Source Homo sapiens (Human) (DPOLL_HUMAN) Sequence A:  ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKS FHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHI SESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQAS LTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL DSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLS EHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYR EPAERDW Description Functional site 1) chain A residue 416 type sequence G description binding site for residue MG A 601 source : AC1 2) chain A residue 417 type sequence S description binding site for residue MG A 601 source : AC1 3) chain A residue 427 type sequence D description binding site for residue MG A 601 source : AC1 4) chain A residue 429 type sequence D description binding site for residue MG A 601 source : AC1 5) chain A residue 427 type sequence D description binding site for residue MN A 602 source : AC2 6) chain A residue 429 type sequence D description binding site for residue MN A 602 source : AC2 7) chain A residue 490 type sequence D description binding site for residue MN A 602 source : AC2 8) chain A residue 386 type sequence R description binding site for residue DCP A 603 source : AC3 9) chain A residue 416 type sequence G description binding site for residue DCP A 603 source : AC3 10) chain A residue 417 type sequence S description binding site for residue DCP A 603 source : AC3 11) chain A residue 420 type sequence R description binding site for residue DCP A 603 source : AC3 12) chain A residue 426 type sequence G description binding site for residue DCP A 603 source : AC3 13) chain A residue 427 type sequence D description binding site for residue DCP A 603 source : AC3 14) chain A residue 429 type sequence D description binding site for residue DCP A 603 source : AC3 15) chain A residue 505 type sequence Y description binding site for residue DCP A 603 source : AC3 16) chain A residue 506 type sequence F description binding site for residue DCP A 603 source : AC3 17) chain A residue 507 type sequence T description binding site for residue DCP A 603 source : AC3 18) chain A residue 508 type sequence G description binding site for residue DCP A 603 source : AC3 19) chain A residue 513 type sequence N description binding site for residue DCP A 603 source : AC3 20) chain A residue 339 type sequence S description binding site for residue MN A 604 source : AC4 21) chain A residue 341 type sequence I description binding site for residue MN A 604 source : AC4 22) chain A residue 344 type sequence A description binding site for residue MN A 604 source : AC4 23) chain A residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 25) chain A residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 26) chain A residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 27) chain A residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 28) chain A residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 29) chain A residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 30) chain A residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 31) chain A residue 416-435 type prosite sequence GSYRRGKATCGDVDVLITHP description DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP source prosite : PS00522

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