Title
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Crystal Structure of Yeast V1-ATPase in the Autoinhibited Form |
Classification
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HYDROLASE |
Compound
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V-type proton ATPase catalytic subunit A |
Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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A: |
EYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIR
IDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGPGLME
TIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKWQFT
PGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRSRGTI
TWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRVPRP
VTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCGK
TVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFPELYT
EMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEY
FRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPA
YLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPAGGD
FSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSK
YTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQVVQLV
GKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFCPIWK
TFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVKHAVS
SSKFFEPSRGEKEVHGEFEKLLSTMQERFAE
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B: |
HAESEYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVG
EVIRIDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGP
GLMETIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIK
WQFTPGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRS
RGTITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVR
VPRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAF
GCGKTVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFP
ELYTEMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGIT
LAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQ
GFPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSP
AGGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSV
SYSKYTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQV
VQLVGKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFC
PIWKTFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVK
HAVSSSKFFEPSRGEKEVHGEFEKLLSTMQERFAESTD
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C: |
AESEYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGE
VIRIDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGPG
LMETIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKW
QFTPGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRSR
GTITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRV
PRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFG
CGKTVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFPE
LYTEMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGITL
AEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQG
FPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPA
GGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVS
YSKYTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQVV
QLVGKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFCP
IWKTFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVKH
AVSSSKFFEPSRGEKEVHGEFEKLLSTMQ
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D: |
NYNTVSGVNGPLVILEKVKFPRYNEIVNLTLPDGTVRQGQ
VLEIRGDRAIVQVFEGTSGIDVKKTTVEFTGESLRIPVSE
DMLGRIFDGSGRPIDNGPKVFAEDYLDINGSPINPYARIY
PEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ
ICRQAGLVRPTKDGHEENFSIVFAAMGVNLETARFFKQDF
EENGSLERTSLFLNLANDPTIERIITPRLALTTAEYLAYQ
TERHVLTILTDMSSYADALREVSAAREEVPGRRGYPGYMY
TDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDL
TGYITEGQIFVDRQLHNKGIYPPINVLPSLSRLMKSAIGE
GMTRKDHGDVSNQLYAKYAIGKDAAAMKAVVGEEALSIED
KLSLEFLEKFEKTFITQGAYEDRTVFESLDQAWSLLRIYP
KEMLNRISPKILDEFYD
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E: |
NYNTVSGVNGPLVILEKVKFPRYNEIVNLTLPDGTVRQGQ
VLEIRGDRAIVQVFEGTSGIDVKKTTVEFTGESLRIPVSE
DMLGRIFDGSGRPIDNGPKVFAEDYLDINGSPINPYARIY
PEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ
ICRQAGLVRPTKENFSIVFAAMGVNLETARFFKQDFEENG
SLERTSLFLNLANDPTIERIITPRLALTTAEYLAYQTERH
VLTILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLS
TIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYI
TEGQIFVDRQLHNKGIYPPINVLPSLSRLMKSAIGEGMTR
KDHGDVSNQLYAKYAIGKDAAAMKAVVGEEALSIEDKLSL
EFLEKFEKTFITQGAYEDRTVFESLDQAWSLLRIYPKEML
NRISPKILDEFYD
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F: |
NYNTVSGVNGPLVILEKVKFPRYNEIVNLTLPDGTVRQGQ
VLEIRGDRAIVQVFEGTSGIDVKKTTVEFTGESLRIPVSE
DMLGRIFDGSGRPIDNGPKVFAEDYLDINGSPINPYARIY
PEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ
ICRQAGENFSIVFAAMGVNLETARFFKQDFEENGSLERTS
LFLNLANDPTIERIITPRLALTTAEYLAYQTERHVLTILT
DMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERA
GRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIF
VDRQLHNKGIYPPINVLPSLSRLMKSAIGEGMTRKDHGDV
SNQLYAKYAIGKDAAAMKAVVGEEALSIEDKLSLEFLEKF
EKTFITQGAYEDRTVFESLDQAWSLLRIYPKEMLNRISPK
ILDEFYD
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G: |
NREQVFPTRMTLGLMKTKLKGANQGYSLLKRKSEALTKRF
RDITKRIDDAKQKMGRVMQTAAFSLAEVSYATGENIGYQV
QESVSTARFKVRARQENVSGVYLSQFESYIDPEINDFRLT
GLGRGGQQVQRAKEIYSRAVETLVELASLQTAFIILDEVI
KVTNRRVNAIEHVIIPRTENTIAYINSELDELDREEFYRL
KKVQEKKQNETAKLDAEMKLKRD
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H: |
GATKILMDSTHFNEIRSIIRSRSVAWDALARSEELSEIDA
STAKALESILVKKVNGKTLIPLIHLLSTSDNEDCKKSVQN
LIAELLSSDKYGDDTVKFFQEDPKQLEQLFDVSLKGDFQT
VLISGFNVVSLLVQNGLHNVKLVEKLLKNNNLINILQNIE
QMDTCYVCIRLLQELAVIPEYRDVIWLHEKKFMPTLFKIL
QRATDHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDF
LDLLKLVKITIKEKVSRLCISIILQCCSTRVKQHKKVIKQ
LLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQ
ELTSFDEYVAELDSKLLCWSPPHVDNGFWSDNIDEFKKDN
YKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVV
ELLPESIDVLDKTGGKADIMELLNHSDSRVKYEALKATQA
IIGYT
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I: |
TPNQVNDELNKMQAFIRKEAEEKAKEIQLKADQEYEIEKT
NIVRNETNNIDGNFKSKLKKAMLSQQITKSTIANKMRLKV
LSAREQSLDGIFEETKEKLSGIANNRDEYKPILQSLIVEA
LLKLLEPKAIVKALERDVDLIESMKDDIMREYGEKAQRAP
LEEIVISNDYLNKDLVSGGVVVSNASDKIEINNTLEERLK
LLSEEALPAIRLELYG
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J: |
QKNGIATLLQAEKEAHEIVSKARKYRQDKLKQAKTDAAKE
IDSYKIQKDKELKEFEQKNAGGVGELEKKAEAGVQGELAE
IKKIAEKKKDDVVKILIETVIKPS
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K: |
AFIRKEAEEKAKEIQLKADQEYEIEKTNIVRNETNNIDGN
FKSKLKKAMLSQQITKSTIANKMRLKVLSAREQSLDGIFE
ETKEKLSGIANNRDEYKPILQSLIVEALLKLLEPKAIVKA
LERDVDLIESMKDDIMREYGEKAQRAPLEEIVISNDYLNK
DLVSGGVVVSNASDKIEINNTLEERLKLLSEEALPAIRLE
LYG
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L: |
EIVSKARKYRQDKLKQAKTDAAKEIDSYKIQKDKELKEFE
QKNAGGVGELEKKAEAGVQGELAEIKKIAEKKKDDVVKIL
IETVIKPS
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M: |
AFIRKEAEEKAKEIQLKADQEYEIEKTNIVRNETNNIDGN
FKSKLKKAMLSQQITKSTIANKMRLKVLSAREQSLDGIFE
ETKEKLSGIANNRDEYKPILQSLIVEALLKLLEPKAIVKA
LERDVDLIESMKDDIMREYGEKAQRAPLEEIVISNDYLNK
DLVSGGVVVSNASDKIEINNTLEERLKLLSEEALPAIRLE
LYG
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N: |
KYRQDKLKQAKTDAAKEIDSYKIQKDKELKEFEQKNAGGV
GELEKKAEAGVQGELAEIKKIAEKKKDDVVKILIETVIKP
S
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O: |
AEKRTLIAVIADEDTTTGLLLAGIGQITPETQEKNFFVYQ
EGKTTKEEITDKFNHFTEERDDIAILLINQHIAENIRARV
DSFTNAFPAILEIPSKDHPYDPEKDSVLKRVRKLF
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a: |
EYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIR
IDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGPGLME
TIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKWQFT
PGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRSRGTI
TWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRVPRP
VTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCGK
TVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFPELYT
EMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEY
FRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPA
YLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPAGGD
FSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSK
YTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQVVQLV
GKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFCPIWK
TFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVKHAVS
SSKFFEPSRGEKEVHGEFEKLLSTMQERFAE
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b: |
HAESEYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVG
EVIRIDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGP
GLMETIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIK
WQFTPGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRS
RGTITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVR
VPRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAF
GCGKTVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFP
ELYTEMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGIT
LAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQ
GFPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSP
AGGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSV
SYSKYTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQV
VQLVGKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFC
PIWKTFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVK
HAVSSSKFFEPSRGEKEVHGEFEKLLSTMQERFAESTD
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c: |
AESEYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGE
VIRIDGDKATIQVYEETAGLTVGDPVLRTGKPLSVELGPG
LMETIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKW
QFTPGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRSR
GTITWIAPAGEYTLDEKILEVEFDGKKSDFTLYHTWPVRV
PRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFG
CGKTVISQSLSKYSNSDAIIYVGCGERGNEMAEVLMEFPE
LYTEMSGTKEPIMKRTTLVANTSNMPVAAREASIYTGITL
AEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQG
FPAYLGAKLASFYERAGKAVALGSPDRTGSVSIVAAVSPA
GGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVS
YSKYTNVLNKFYDSNYPEFPVLRDRMKEILSNAEELEQVV
QLVGKSALSDSDKITLDVATLIKEDFLQQNGYSTYDAFCP
IWKTFDMMRAFISYHDEAQKAVANGANWSKLADSTGDVKH
AVSSSKFFEPSRGEKEVHGEFEKLLSTMQ
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d: |
NYNTVSGVNGPLVILEKVKFPRYNEIVNLTLPDGTVRQGQ
VLEIRGDRAIVQVFEGTSGIDVKKTTVEFTGESLRIPVSE
DMLGRIFDGSGRPIDNGPKVFAEDYLDINGSPINPYARIY
PEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ
ICRQAGLVRPTKGHEENFSIVFAAMGVNLETARFFKQDFE
ENGSLERTSLFLNLANDPTIERIITPRLALTTAEYLAYQT
ERHVLTILTDMSSYADALREVSAAREEVPGRRGYPGYMYT
DLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLT
GYITEGQIFVDRQLHNKGIYPPINVLPSLSRLMKSAIGEG
MTRKDHGDVSNQLYAKYAIGKDAAAMKAVVGEEALSIEDK
LSLEFLEKFEKTFITQGAYEDRTVFESLDQAWSLLRIYPK
EMLNRISPKILDEFYD
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e: |
NYNTVSGVNGPLVILEKVKFPRYNEIVNLTLPDGTVRQGQ
VLEIRGDRAIVQVFEGTSGIDVKKTTVEFTGESLRIPVSE
DMLGRIFDGSGRPIDNGPKVFAEDYLDINGSPINPYARIY
PEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ
ICRQAGLVRPTKENFSIVFAAMGVNLETARFFKQDFEENG
SLERTSLFLNLANDPTIERIITPRLALTTAEYLAYQTERH
VLTILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLS
TIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYI
TEGQIFVDRQLHNKGIYPPINVLPSLSRLMKSAIGEGMTR
KDHGDVSNQLYAKYAIGKDAAAMKAVVGEEALSIEDKLSL
EFLEKFEKTFITQGAYEDRTVFESLDQAWSLLRIYPKEML
NRISPKILDEFYD
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f: |
NYNTVSGVNGPLVILEKVKFPRYNEIVNLTLPDGTVRQGQ
VLEIRGDRAIVQVFEGTSGIDVKKTTVEFTGESLRIPVSE
DMLGRIFDGSGRPIDNGPKVFAEDYLDINGSPINPYARIY
PEEMISTGVSAIDTMNSIARGQKIPIFSASGLPHNEIAAQ
ICRQAGHEENFSIVFAAMGVNLETARFFKQDFEENGSLER
TSLFLNLANDPTIERIITPRLALTTAEYLAYQTERHVLTI
LTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYE
RAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQ
IFVDRQLHNKGIYPPINVLPSLSRLMKSAIGEGMTRKDHG
DVSNQLYAKYAIGKDAAAMKAVVGEEALSIEDKLSLEFLE
KFEKTFITQGAYEDRTVFESLDQAWSLLRIYPKEMLNRIS
PKILDEFYD
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g: |
QVFPTRMTLGLMKTKLKGANQGYSLLKRKSEALTKRFRDI
TKRIDDAKQKMGRVMQTAAFSLAEVSYATGENIGYQVQES
VSTARFKVRARQENVSGVYLSQFESYIDPEINDFRLTGLG
RGGQQVQETLVELASLQTAFIILDEVIKVTNRRVNAIEHV
IIPRTENTIAYINSELDELDREEFYRLKKVQEKKQNETAK
LDAEMKLKRDRA
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h: |
GATKILMDSTHFNEIRSIIRSRSVAWDALARSEELSEIDA
STAKALESILVKKVNGKTLIPLIHLLSTSDNEDCKKSVQN
LIAELLSSDKYGDDTVKFFQEDPKQLEQLFDVSLKGDFQT
VLISGFNVVSLLVQNGLHNVKLVEKLLKNNNLINILQNIE
QMDTCYVCIRLLQELAVIPEYRDVIWLHEKKFMPTLFKIL
QRATDHLGIQLQYHSLLLIWLLTFNPVFANELVQKYLSDF
LDLLKLVKITIKEKVSRLCISIILQCCSTRVKQHKKVIKQ
LLLLGNALPTVQSLSERKYSDEELRQDISNLKEILENEYQ
ELTSFDEYVAELDSKLLCWSPPHVDNGFWSDNIDEFKKDN
YKIFRQLIELLQAKVRNGDVNAKQEKIIIQVALNDITHVV
ELLPESIDVLDKTGGKADIMELLNHSDSRVKYEALKATQA
IIGYT
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i: |
TPNQVNDELNKMQAFIRKEAEEKAKEIQLKADQEYEIEKT
NIVRNETNNIDGNFKSKLKKAMLSQQITKSTIANKMRLKV
LSAREQSLDGIFEETKEKLSGIANNRDEYKPILQSLIVEA
LLKLLEPKAIVKALERDVDLIESMKDDIMREYGEKAQRAP
LEEIVISNDYLNKDLVSGGVVVSNASDKIEINNTLEERLK
LLSEEALPAIRLELYG
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j: |
QKNGIATLLQAEKEAHEIVSKARKYRQDKLKQAKTDAAKE
IDSYKIQKDKELKEFEQKNAGGVGELEKKAEAGVQGELAE
IKKIAEKKKDDVVKILIETVIKPS
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k: |
KTNIVRNETNNIDGNFKSKLKKAMLSQQITKSTIANKMRL
KVLSAREQSLDGIFEETKEKLSGIANNRDEYKPILQSLIV
EALLKLLEPKAIVKALERDVDLIESMKDDIMREYGEKAQR
APLEEIVISNDYLNKDLVSGGVVVSNASDKIEINNTLEER
LKLLSEEALPAIRLELYG
|
l: |
AAKEIDSYKIQKDKELKEFEQKNAGGVGELEKKAEAGVQG
ELAEIKKIAEKKKDDVVKILIETVIKPS
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m: |
LNKMQAFIRKEAEEKAKEIQLKADQEYEIEKTNIVRNETN
NIDGNFKSKLKKAMLSQQITKSTIANKMRLKVLSAREQSL
DGIFEETKEKLSGIANNRDEYKPILQSLIVEALLKLLEPK
AIVKALERDVDLIESMKDDIMREYGEKAQRAPLEEIVISN
DYLNKDLVSGGVVVSNASDKIEINNTLEERLKLLSEEALP
AIRLELYG
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n: |
SQKNGIATLLQAEKEAHEIVSKARKYRQDKLKQAKTDAAK
EIDSYKIQKDKELKEFEQKNAGGVGELEKKAEAGVQGELA
EIKKIAEKKKDDVVKILIETVIKPS
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o: |
AEKRTLIAVIADEDTTTGLLLAGIGQITPETQEKNFFVYQ
EGKTTKEEITDKFNHFTEERDDIAILLINQHIAENIRARV
DSFTNAFPAILEIPSKDHPYDPEKDSVLKRVRKLF
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Description
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