eF-site ID 5d5b-A PDB Code 5d5b Chain A click to enlarge Title In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K Classification Membrane Protein/Hydrolase Compound Beta-2 adrenergic receptor,Endolysin,Beta-2 adrenergic receptor Source (ADRB2_HUMAN) Sequence A:  DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVT NYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEF WTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKN KARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEE TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKR QLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSL NAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGIL RNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLR MLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWD AYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL CL Description Functional site 1) chain A residue 1011 type catalytic sequence E description 921 source MCSA : MCSA1 2) chain A residue 1020 type catalytic sequence D description 921 source MCSA : MCSA1 3) chain A residue 59-71 type TOPO_DOM sequence AKFERLQTVTNYF description Cytoplasmic source Swiss-Prot : SWS_FT_FI3 4) chain A residue 130-150 type TOPO_DOM sequence DRYFAITSPFKYQSLLTKNKA description Cytoplasmic source Swiss-Prot : SWS_FT_FI3 5) chain A residue 72-95 type TRANSMEM sequence ITSLACADLVMGLAVVPFGAAHIL description Helical; Name=2 source Swiss-Prot : SWS_FT_FI4 6) chain A residue 107-129 type TRANSMEM sequence EFWTSIDVLCVTASIETLCVIAV description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 7) chain A residue 151-174 type TRANSMEM sequence RVIILMVWIVSGLTSFLPIQMHWY description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 8) chain A residue 197-220 type TRANSMEM sequence QAYAIASSIVSFYVPLVIMVFVYS description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 9) chain A residue 275-298 type TRANSMEM sequence LGIIMGTFTLCWLPFFIVNIVHVI description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 10) chain A residue 306-329 type TRANSMEM sequence EVYILLNWIGYVNSGFNPLIYCRS description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 11) chain A residue 113 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 12) chain A residue 118 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 13) chain A residue 293 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 14) chain A residue 312 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 15) chain A residue 316 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 16) chain A residue 203 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17952055, ECO:0000269|PubMed:17962520, ECO:0007744|PDB:2RH1 source Swiss-Prot : SWS_FT_FI11 17) chain A residue 141 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8521811 source Swiss-Prot : SWS_FT_FI12 18) chain A residue 265 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI15 19) chain A residue 341 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:17962520, ECO:0000269|PubMed:18547522, ECO:0000269|PubMed:2540197, ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI16 20) chain A residue 1011 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI18 21) chain A residue 96-106 type TOPO_DOM sequence MKMWTFGNFWC description Extracellular source Swiss-Prot : SWS_FT_FI1 22) chain A residue 175-196 type TOPO_DOM sequence RATHQEAINCYAEETCCDFFTN description Extracellular source Swiss-Prot : SWS_FT_FI1 23) chain A residue 299-305 type TOPO_DOM sequence QDNLIRK description Extracellular source Swiss-Prot : SWS_FT_FI1 24) chain A residue 35-58 type TRANSMEM sequence GMGIVMSLIVLAIVFGNVLVITAI description Helical; Name=1 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 119-135 type prosite sequence ASIETLCVIAVDRYFAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAVDRYFaI source prosite : PS00237 26) chain A residue 1020 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI19 27) chain A residue 1032 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI20 28) chain A residue 1104 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI20 29) chain A residue 1117 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI21 30) chain A residue 1132 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI21

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