eF-site ID 5d0w-b
PDB Code 5d0w
Chain b

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Title Yeast 20S proteasome beta5-T1S mutant
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c);
Sequence b:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK
IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS
VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH
KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS
QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
Description (1)  PROTEASOME SUBUNIT ALPHA TYPE-2 (E.C.3.4.25.1), PROTEASOME SUBUNIT ALPHA TYPE-3 (E.C.3.4.25.1), PROTEASOME SUBUNIT ALPHA TYPE-4 (E.C.3.4.25.1), PROTEASOME SUBUNIT ALPHA TYPE-5 (E.C.3.4.25.1), PROTEASOME SUBUNIT ALPHA TYPE-6 (E.C.3.4.25.1), PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 (E.C.3.4.25.1), PROTEASOME SUBUNIT ALPHA TYPE-1 (E.C.3.4.25.1), PROTEASOME SUBUNIT BETA TYPE-2 (E.C.3.4.25.1), PROTEASOME SUBUNIT BETA TYPE-3 (E.C.3.4.25.1), PROTEASOME SUBUNIT BETA TYPE-4 (E.C.3.4.25.1), PROTEASOME SUBUNIT BETA TYPE-5 (E.C.3.4.25.1), PROTEASOME SUBUNIT BETA TYPE-6 (E.C.3.4.25.1), PROTEASOME SUBUNIT BETA TYPE-7 (E.C.3.4.25.1), PROTEASOME SUBUNIT BETA TYPE-1 (E.C.3.4.25.1), 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE


Functional site

1) chain b
residue 4-51
type prosite
ligand
sequence MAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWC
CRSGSAAD
description Proteasome beta-type subunits signature.[LIVMACFT]-[GSA]-[LIVMF]-x-[FYLVGAC]-x(2)-[GSACFYI]-[LIVMSTACF]-[LIVMSTAC]-[LIVMFSTAC]-[GACI]-[GSTACV]-[DES]-x(15,16)-[RK]-x(12,13)-G-x(2)-[GSTA]-D.
source prosite : PS00854


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