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eF-site ID
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5czi-A |
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PDB Code
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5czi |
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Chain
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A |
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click to enlarge
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Title
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EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE |
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Classification
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TRANSFERASE |
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Compound
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Epidermal growth factor receptor |
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Source
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Homo sapiens (Human) (5CZI) |
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Sequence
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A: |
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEG
EKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC
RLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLL
NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS
DVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ
PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP
QRYLVIQGDERMHLPDEDMDDVVDADEYLI
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Description
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Functional site
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1)
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chain |
A |
| residue |
718-745 |
| type |
prosite |
| sequence |
LGSGAFGTVYKGLWIPEGEKVKIPVAIK
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| description |
PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK
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| source |
prosite : PS00107
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2)
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chain |
A |
| residue |
833-845 |
| type |
prosite |
| sequence |
LVHRDLAARNVLV
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| description |
PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV
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| source |
prosite : PS00109
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3)
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chain |
A |
| residue |
1016 |
| type |
MOD_RES |
| sequence |
Y
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| description |
Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0000269|PubMed:23774213
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| source |
Swiss-Prot : SWS_FT_FI13
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4)
|
chain |
A |
| residue |
716 |
| type |
CROSSLNK |
| sequence |
K
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| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
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| source |
Swiss-Prot : SWS_FT_FI14
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5)
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chain |
A |
| residue |
737 |
| type |
CROSSLNK |
| sequence |
K
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| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
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| source |
Swiss-Prot : SWS_FT_FI14
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6)
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chain |
A |
| residue |
754 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
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| source |
Swiss-Prot : SWS_FT_FI14
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7)
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chain |
A |
| residue |
867 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
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| source |
Swiss-Prot : SWS_FT_FI14
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8)
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chain |
A |
| residue |
929 |
| type |
CROSSLNK |
| sequence |
K
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| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144
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| source |
Swiss-Prot : SWS_FT_FI15
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9)
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chain |
A |
| residue |
970 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144
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| source |
Swiss-Prot : SWS_FT_FI15
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10)
|
chain |
A |
| residue |
757 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800
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| source |
Swiss-Prot : SWS_FT_FI16
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11)
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chain |
A |
| residue |
960 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800
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| source |
Swiss-Prot : SWS_FT_FI16
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12)
|
chain |
A |
| residue |
718 |
| type |
BINDING |
| sequence |
L
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| description |
BINDING => ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
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| source |
Swiss-Prot : SWS_FT_FI2
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13)
|
chain |
A |
| residue |
745 |
| type |
BINDING |
| sequence |
K
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| description |
BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
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| source |
Swiss-Prot : SWS_FT_FI3
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14)
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chain |
A |
| residue |
790 |
| type |
BINDING |
| sequence |
T
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| description |
BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
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| source |
Swiss-Prot : SWS_FT_FI4
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15)
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chain |
A |
| residue |
855 |
| type |
BINDING |
| sequence |
D
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| description |
BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
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| source |
Swiss-Prot : SWS_FT_FI5
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16)
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chain |
A |
| residue |
1016 |
| type |
SITE |
| sequence |
Y
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| description |
Important for interaction with PIK3C2B
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| source |
Swiss-Prot : SWS_FT_FI6
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17)
|
chain |
A |
| residue |
745 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674
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| source |
Swiss-Prot : SWS_FT_FI8
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18)
|
chain |
A |
| residue |
869 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0000269|PubMed:23774213
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| source |
Swiss-Prot : SWS_FT_FI9
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