|
eF-site ID
|
5czi-A |
PDB Code
|
5czi |
Chain
|
A |
|
click to enlarge
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Title
|
EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE |
Classification
|
TRANSFERASE |
Compound
|
Epidermal growth factor receptor |
Source
|
Homo sapiens (Human) (5CZI) |
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Sequence
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A: |
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEG
EKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC
RLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLL
NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS
DVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ
PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP
QRYLVIQGDERMHLPDEDMDDVVDADEYLI
|
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Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
718-745 |
type |
prosite |
sequence |
LGSGAFGTVYKGLWIPEGEKVKIPVAIK
|
description |
PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK
|
source |
prosite : PS00107
|
|
2)
|
chain |
A |
residue |
833-845 |
type |
prosite |
sequence |
LVHRDLAARNVLV
|
description |
PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV
|
source |
prosite : PS00109
|
|
3)
|
chain |
A |
residue |
1016 |
type |
MOD_RES |
sequence |
Y
|
description |
Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0000269|PubMed:23774213
|
source |
Swiss-Prot : SWS_FT_FI13
|
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4)
|
chain |
A |
residue |
716 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
|
source |
Swiss-Prot : SWS_FT_FI14
|
|
5)
|
chain |
A |
residue |
737 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
|
source |
Swiss-Prot : SWS_FT_FI14
|
|
6)
|
chain |
A |
residue |
754 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
|
source |
Swiss-Prot : SWS_FT_FI14
|
|
7)
|
chain |
A |
residue |
867 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
|
source |
Swiss-Prot : SWS_FT_FI14
|
|
8)
|
chain |
A |
residue |
929 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144
|
source |
Swiss-Prot : SWS_FT_FI15
|
|
9)
|
chain |
A |
residue |
970 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144
|
source |
Swiss-Prot : SWS_FT_FI15
|
|
10)
|
chain |
A |
residue |
757 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800
|
source |
Swiss-Prot : SWS_FT_FI16
|
|
11)
|
chain |
A |
residue |
960 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800
|
source |
Swiss-Prot : SWS_FT_FI16
|
|
12)
|
chain |
A |
residue |
718 |
type |
BINDING |
sequence |
L
|
description |
BINDING => ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
13)
|
chain |
A |
residue |
745 |
type |
BINDING |
sequence |
K
|
description |
BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
14)
|
chain |
A |
residue |
790 |
type |
BINDING |
sequence |
T
|
description |
BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
|
source |
Swiss-Prot : SWS_FT_FI4
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|
15)
|
chain |
A |
residue |
855 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
16)
|
chain |
A |
residue |
1016 |
type |
SITE |
sequence |
Y
|
description |
Important for interaction with PIK3C2B
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
17)
|
chain |
A |
residue |
745 |
type |
MOD_RES |
sequence |
K
|
description |
N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674
|
source |
Swiss-Prot : SWS_FT_FI8
|
|
18)
|
chain |
A |
residue |
869 |
type |
MOD_RES |
sequence |
Y
|
description |
Phosphotyrosine => ECO:0000269|PubMed:23774213
|
source |
Swiss-Prot : SWS_FT_FI9
|
|
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