eF-site ID 5cz8-a
PDB Code 5cz8
Chain a

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Title Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c);
Sequence a:  TQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVE
RLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPL
ADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQ
SNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVD
RESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAII
DKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI
Description


Functional site
1) chain a
residue 12-59
type prosite
sequence ISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVV
GISGDISD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. ISMkYdnGVIIAADnlgsygsllrfngve.RlipvgdntvvgisGdiSD
source prosite : PS00854

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