|
eF-site ID
|
5cz8-I |
PDB Code
|
5cz8 |
Chain
|
I |
|
click to enlarge
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Title
|
Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib |
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
Compound
|
Proteasome subunit alpha type-2 |
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); |
|
Sequence
|
I: |
SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFE
KIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERA
IEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFI
AGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPE
DLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK
MRQD
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Description
|
|
Functional site
|
|
1)
|
chain |
I |
residue |
124 |
type |
|
sequence |
D
|
description |
binding site for residue 3BV H 301
|
source |
: AC4
|
|
2)
|
chain |
I |
residue |
204 |
type |
|
sequence |
D
|
description |
binding site for residue MG I 301
|
source |
: AC6
|
|
3)
|
chain |
I |
residue |
12-58 |
type |
prosite |
sequence |
VAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLG
ITGLATD
|
description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. ISMkYdnGVIIAADnlgsygsllrfngve.RlipvgdntvvgisGdiSD
|
source |
prosite : PS00854
|
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