eF-site ID 5cz8-H
PDB Code 5cz8
Chain H

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Title Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c);
Sequence H:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK
IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL
QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD
VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ
AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ
KSYKFPRGTTAVLKESIVNICD
Description


Functional site

1) chain H
residue 69
type
sequence Y
description binding site for residue CL G 303
source : AC3

2) chain H
residue 1
type
sequence T
description binding site for residue 3BV H 301
source : AC4

3) chain H
residue 19
type
sequence R
description binding site for residue 3BV H 301
source : AC4

4) chain H
residue 20
type
sequence S
description binding site for residue 3BV H 301
source : AC4

5) chain H
residue 21
type
sequence T
description binding site for residue 3BV H 301
source : AC4

6) chain H
residue 27
type
sequence A
description binding site for residue 3BV H 301
source : AC4

7) chain H
residue 47
type
sequence G
description binding site for residue 3BV H 301
source : AC4

8) chain H
residue 48
type
sequence T
description binding site for residue 3BV H 301
source : AC4

9) chain H
residue 49
type
sequence A
description binding site for residue 3BV H 301
source : AC4

10) chain H
residue 168
type
sequence G
description binding site for residue 3BV H 301
source : AC4

11) chain H
residue 47
type
sequence G
description binding site for residue MES H 302
source : AC5

12) chain H
residue 129
type
sequence S
description binding site for residue MES H 302
source : AC5

13) chain H
residue 114
type
sequence H
description binding site for residue 3BV N 201
source : AC9

14) chain H
residue 116
type
sequence H
description binding site for residue 3BV N 201
source : AC9

15) chain H
residue 118
type
sequence S
description binding site for residue 3BV N 201
source : AC9

16) chain H
residue 120
type
sequence D
description binding site for residue 3BV N 201
source : AC9

17) chain H
residue 1
type catalytic
sequence T
description 177
source MCSA : MCSA1

18) chain H
residue 17
type catalytic
sequence D
description 177
source MCSA : MCSA1

19) chain H
residue 19
type catalytic
sequence R
description 177
source MCSA : MCSA1

20) chain H
residue 33
type catalytic
sequence K
description 177
source MCSA : MCSA1

21) chain H
residue 47
type catalytic
sequence G
description 177
source MCSA : MCSA1

22) chain H
residue 129
type catalytic
sequence S
description 177
source MCSA : MCSA1

23) chain H
residue 166
type catalytic
sequence D
description 177
source MCSA : MCSA1

24) chain H
residue 169
type catalytic
sequence S
description 177
source MCSA : MCSA1

25) chain H
residue 4-51
type prosite
sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC
AGAGTAAD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIaGedFAVLAGDtrnitdysinsryep.KvfdcgdnivmsanGfaAD
source prosite : PS00854


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