eF-site ID 5cz8-Y PDB Code 5cz8 Chain Y click to enlarge Title Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence Y:  DCKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTV KAVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREK ERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPT IYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVE DALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNH DVGELFWKVKEEEGSFNNVIG Description Functional site 1) chain Y residue 165 type sequence A description binding site for residue MG I 301 source : AC6 2) chain Y residue 168 type sequence D description binding site for residue MG I 301 source : AC6 3) chain Y residue 169 type sequence A description binding site for residue MG I 301 source : AC6 4) chain Y residue 171 type sequence S description binding site for residue MG I 301 source : AC6 5) chain Y residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2

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