eF-site ID 5cz8-U PDB Code 5cz8 Chain U click to enlarge Title Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence U:  GYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDC TVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDA RNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQ RAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATA TGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHM IDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAE Q Description Functional site 1) chain U residue 65 type sequence C description binding site for residue MG U 301 source : AD3 2) chain U residue 111 type sequence R description binding site for residue CL U 302 source : AD4 3) chain U residue 114 type sequence N description binding site for residue CL U 302 source : AD4 4) chain U residue 223 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 source Swiss-Prot : SWS_FT_FI3

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