eF-site ID 5cz8-K PDB Code 5cz8 Chain K click to enlarge Title Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence K:  CKIKIAHGTTTLAFRFQGGIIVAVDSRATAGNWVASQTVK AVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKE RISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTI YYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVED ALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHD VGELFWKVKEEEGSFNNVIG Description Functional site 1) chain K residue 165 type sequence A description binding site for residue MG K 301 source : AC7 2) chain K residue 166 type sequence H description binding site for residue MG K 301 source : AC7 3) chain K residue 168 type sequence D description binding site for residue MG K 301 source : AC7 4) chain K residue 169 type sequence A description binding site for residue MG K 301 source : AC7 5) chain K residue 171 type sequence S description binding site for residue MG K 301 source : AC7 6) chain K residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2

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