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eF-site ID
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5cz8-I |
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PDB Code
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5cz8 |
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Chain
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I |
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click to enlarge
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Title
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Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome subunit alpha type-2 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); |
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Sequence
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I: |
SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFE
KIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERA
IEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFI
AGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPE
DLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLK
MRQD
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Description
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Functional site
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1)
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chain |
I |
| residue |
124 |
| type |
|
| sequence |
D
|
| description |
binding site for residue 3BV H 301
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| source |
: AC4
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2)
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chain |
I |
| residue |
204 |
| type |
|
| sequence |
D
|
| description |
binding site for residue MG I 301
|
| source |
: AC6
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3)
|
chain |
I |
| residue |
12-58 |
| type |
prosite |
| sequence |
VAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLG
ITGLATD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. ISMkYdnGVIIAADnlgsygsllrfngve.RlipvgdntvvgisGdiSD
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| source |
prosite : PS00854
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