eF-site ID 5cwr-B PDB Code 5cwr Chain B click to enlarge Title Crystal Structure of human DNA polymerase lambda L431A mutant in complex with a one nucleotide DNA gap and dCTP Classification TRANSFERASE/DNA Compound DNA polymerase lambda Source Homo sapiens (Human) (5CWR) Sequence B:  TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSF HKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHIS ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASL TTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSG LLCVACGSYRRGKATCGDVDVAITHPDGRSHRGIFSRLLD SLRQEGFLTDDLVSQGQQQKYLGVCRLPGPGRRHRRLDII VVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHAL STAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAE RDW Description Functional site 1) chain B residue 386 type sequence R description binding site for residue DCP B 601 source : AC4 2) chain B residue 416 type sequence G description binding site for residue DCP B 601 source : AC4 3) chain B residue 417 type sequence S description binding site for residue DCP B 601 source : AC4 4) chain B residue 420 type sequence R description binding site for residue DCP B 601 source : AC4 5) chain B residue 426 type sequence G description binding site for residue DCP B 601 source : AC4 6) chain B residue 427 type sequence D description binding site for residue DCP B 601 source : AC4 7) chain B residue 429 type sequence D description binding site for residue DCP B 601 source : AC4 8) chain B residue 505 type sequence Y description binding site for residue DCP B 601 source : AC4 9) chain B residue 506 type sequence F description binding site for residue DCP B 601 source : AC4 10) chain B residue 507 type sequence T description binding site for residue DCP B 601 source : AC4 11) chain B residue 508 type sequence G description binding site for residue DCP B 601 source : AC4 12) chain B residue 510 type sequence A description binding site for residue DCP B 601 source : AC4 13) chain B residue 513 type sequence N description binding site for residue DCP B 601 source : AC4 14) chain B residue 427 type sequence D description binding site for residue CA B 602 source : AC5 15) chain B residue 429 type sequence D description binding site for residue CA B 602 source : AC5 16) chain B residue 490 type sequence D description binding site for residue CA B 602 source : AC5 17) chain B residue 427 type sequence D description binding site for residue CA B 603 source : AC6 18) chain B residue 429 type sequence D description binding site for residue CA B 603 source : AC6 19) chain B residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 21) chain B residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 22) chain B residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 23) chain B residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 24) chain B residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 25) chain B residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 26) chain B residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3

Display surface Download Links