eF-site ID 5cwr-ABCDEFPT PDB Code 5cwr Chain A, B, C, D, E, F, P, T click to enlarge Title Crystal Structure of human DNA polymerase lambda L431A mutant in complex with a one nucleotide DNA gap and dCTP Classification TRANSFERASE/DNA Compound DNA polymerase lambda Source Homo sapiens (Human) (5CWR) Sequence A:  TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSF HKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHIS ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASL TTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSG LLCVACGSYRRGKATCGDVDVAITHPDGRSHRGIFSRLLD SLRQEGFLTDDLVSQEENGQQKYLGVCRLPGPGRRHRRLD IIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEH ALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREP AERDW B:  TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSF HKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHIS ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASL TTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSG LLCVACGSYRRGKATCGDVDVAITHPDGRSHRGIFSRLLD SLRQEGFLTDDLVSQGQQQKYLGVCRLPGPGRRHRRLDII VVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHAL STAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAE RDW C:  GCCG D:  GCCG E:  CAGTAC F:  CGGCGGTACTG P:  CAGTAC T:  CGGCGGTACTG Description Functional site 1) chain A residue 386 type sequence R description binding site for residue DCP A 601 source : AC1 2) chain A residue 416 type sequence G description binding site for residue DCP A 601 source : AC1 3) chain A residue 417 type sequence S description binding site for residue DCP A 601 source : AC1 4) chain A residue 420 type sequence R description binding site for residue DCP A 601 source : AC1 5) chain A residue 426 type sequence G description binding site for residue DCP A 601 source : AC1 6) chain A residue 427 type sequence D description binding site for residue DCP A 601 source : AC1 7) chain A residue 429 type sequence D description binding site for residue DCP A 601 source : AC1 8) chain A residue 505 type sequence Y description binding site for residue DCP A 601 source : AC1 9) chain A residue 506 type sequence F description binding site for residue DCP A 601 source : AC1 10) chain A residue 507 type sequence T description binding site for residue DCP A 601 source : AC1 11) chain A residue 508 type sequence G description binding site for residue DCP A 601 source : AC1 12) chain A residue 510 type sequence A description binding site for residue DCP A 601 source : AC1 13) chain A residue 513 type sequence N description binding site for residue DCP A 601 source : AC1 14) chain P residue 6 type sequence C description binding site for residue DCP A 601 source : AC1 15) chain T residue 5 type sequence G description binding site for residue DCP A 601 source : AC1 16) chain A residue 427 type sequence D description binding site for residue CA A 602 source : AC2 17) chain A residue 429 type sequence D description binding site for residue CA A 602 source : AC2 18) chain A residue 490 type sequence D description binding site for residue CA A 602 source : AC2 19) chain P residue 6 type sequence C description binding site for residue CA A 602 source : AC2 20) chain A residue 427 type sequence D description binding site for residue CA A 603 source : AC3 21) chain A residue 429 type sequence D description binding site for residue CA A 603 source : AC3 22) chain B residue 386 type sequence R description binding site for residue DCP B 601 source : AC4 23) chain B residue 416 type sequence G description binding site for residue DCP B 601 source : AC4 24) chain B residue 417 type sequence S description binding site for residue DCP B 601 source : AC4 25) chain B residue 420 type sequence R description binding site for residue DCP B 601 source : AC4 26) chain B residue 426 type sequence G description binding site for residue DCP B 601 source : AC4 27) chain B residue 427 type sequence D description binding site for residue DCP B 601 source : AC4 28) chain B residue 429 type sequence D description binding site for residue DCP B 601 source : AC4 29) chain B residue 505 type sequence Y description binding site for residue DCP B 601 source : AC4 30) chain B residue 506 type sequence F description binding site for residue DCP B 601 source : AC4 31) chain B residue 507 type sequence T description binding site for residue DCP B 601 source : AC4 32) chain B residue 508 type sequence G description binding site for residue DCP B 601 source : AC4 33) chain B residue 510 type sequence A description binding site for residue DCP B 601 source : AC4 34) chain B residue 513 type sequence N description binding site for residue DCP B 601 source : AC4 35) chain E residue 6 type sequence C description binding site for residue DCP B 601 source : AC4 36) chain F residue 5 type sequence G description binding site for residue DCP B 601 source : AC4 37) chain B residue 427 type sequence D description binding site for residue CA B 602 source : AC5 38) chain B residue 429 type sequence D description binding site for residue CA B 602 source : AC5 39) chain B residue 490 type sequence D description binding site for residue CA B 602 source : AC5 40) chain E residue 6 type sequence C description binding site for residue CA B 602 source : AC5 41) chain B residue 427 type sequence D description binding site for residue CA B 603 source : AC6 42) chain B residue 429 type sequence D description binding site for residue CA B 603 source : AC6 43) chain A residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 46) chain A residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 47) chain A residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 48) chain A residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 49) chain B residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 50) chain B residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 51) chain B residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 52) chain B residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 53) chain A residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 54) chain A residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 55) chain A residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 56) chain B residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 57) chain B residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 58) chain B residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3

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