eF-site ID 5cwr-AB PDB Code 5cwr Chain A, B click to enlarge Title Crystal Structure of human DNA polymerase lambda L431A mutant in complex with a one nucleotide DNA gap and dCTP Classification TRANSFERASE/DNA Compound DNA polymerase lambda Source Homo sapiens (Human) (5CWR) Sequence A:  TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSF HKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHIS ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASL TTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSG LLCVACGSYRRGKATCGDVDVAITHPDGRSHRGIFSRLLD SLRQEGFLTDDLVSQEENGQQKYLGVCRLPGPGRRHRRLD IIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEH ALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREP AERDW B:  TNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSF HKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHIS ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASL TTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSG LLCVACGSYRRGKATCGDVDVAITHPDGRSHRGIFSRLLD SLRQEGFLTDDLVSQGQQQKYLGVCRLPGPGRRHRRLDII VVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHAL STAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAE RDW Description Functional site 1) chain A residue 386 type sequence R description binding site for residue DCP A 601 source : AC1 2) chain A residue 416 type sequence G description binding site for residue DCP A 601 source : AC1 3) chain A residue 417 type sequence S description binding site for residue DCP A 601 source : AC1 4) chain A residue 420 type sequence R description binding site for residue DCP A 601 source : AC1 5) chain A residue 426 type sequence G description binding site for residue DCP A 601 source : AC1 6) chain A residue 427 type sequence D description binding site for residue DCP A 601 source : AC1 7) chain A residue 429 type sequence D description binding site for residue DCP A 601 source : AC1 8) chain A residue 505 type sequence Y description binding site for residue DCP A 601 source : AC1 9) chain A residue 506 type sequence F description binding site for residue DCP A 601 source : AC1 10) chain A residue 507 type sequence T description binding site for residue DCP A 601 source : AC1 11) chain A residue 508 type sequence G description binding site for residue DCP A 601 source : AC1 12) chain A residue 510 type sequence A description binding site for residue DCP A 601 source : AC1 13) chain A residue 513 type sequence N description binding site for residue DCP A 601 source : AC1 14) chain A residue 427 type sequence D description binding site for residue CA A 602 source : AC2 15) chain A residue 429 type sequence D description binding site for residue CA A 602 source : AC2 16) chain A residue 490 type sequence D description binding site for residue CA A 602 source : AC2 17) chain A residue 427 type sequence D description binding site for residue CA A 603 source : AC3 18) chain A residue 429 type sequence D description binding site for residue CA A 603 source : AC3 19) chain B residue 386 type sequence R description binding site for residue DCP B 601 source : AC4 20) chain B residue 416 type sequence G description binding site for residue DCP B 601 source : AC4 21) chain B residue 417 type sequence S description binding site for residue DCP B 601 source : AC4 22) chain B residue 420 type sequence R description binding site for residue DCP B 601 source : AC4 23) chain B residue 426 type sequence G description binding site for residue DCP B 601 source : AC4 24) chain B residue 427 type sequence D description binding site for residue DCP B 601 source : AC4 25) chain B residue 429 type sequence D description binding site for residue DCP B 601 source : AC4 26) chain B residue 505 type sequence Y description binding site for residue DCP B 601 source : AC4 27) chain B residue 506 type sequence F description binding site for residue DCP B 601 source : AC4 28) chain B residue 507 type sequence T description binding site for residue DCP B 601 source : AC4 29) chain B residue 508 type sequence G description binding site for residue DCP B 601 source : AC4 30) chain B residue 510 type sequence A description binding site for residue DCP B 601 source : AC4 31) chain B residue 513 type sequence N description binding site for residue DCP B 601 source : AC4 32) chain B residue 427 type sequence D description binding site for residue CA B 602 source : AC5 33) chain B residue 429 type sequence D description binding site for residue CA B 602 source : AC5 34) chain B residue 490 type sequence D description binding site for residue CA B 602 source : AC5 35) chain B residue 427 type sequence D description binding site for residue CA B 603 source : AC6 36) chain B residue 429 type sequence D description binding site for residue CA B 603 source : AC6 37) chain A residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 312 type ACT_SITE sequence K description Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 40) chain A residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 41) chain A residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 42) chain A residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 43) chain B residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 44) chain B residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 45) chain B residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 46) chain B residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 47) chain A residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 48) chain A residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 49) chain A residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 50) chain B residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 51) chain B residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 52) chain B residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3

Display surface Download Links