eF-site ID 5cqd-A PDB Code 5cqd Chain A click to enlarge Title Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B Classification HYDROLASE Compound DNA dC->dU-editing enzyme APOBEC-3B Source (ABC3B_HUMAN) Sequence A:  MEILRYLMDPDTFTSNFNNDPLVLRRRQTYLCYEVERLDN GTSVKMDQHMGFLCNESGRHAELRFLDLVPSLQLDPAQIY RVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIKAARIY DYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQG CPFQPWDGLEEHSQALSGRLRAILQ Description Functional site 1) chain A residue 253 type sequence H description binding site for residue ZN A 501 source : AC1 2) chain A residue 284 type sequence C description binding site for residue ZN A 501 source : AC1 3) chain A residue 289 type sequence C description binding site for residue ZN A 501 source : AC1 4) chain A residue 211 type sequence R description binding site for residue GOL A 502 source : AC2 5) chain A residue 212 type sequence R description binding site for residue GOL A 502 source : AC2 6) chain A residue 213 type sequence Q description binding site for residue GOL A 502 source : AC2 7) chain A residue 214 type sequence T description binding site for residue GOL A 502 source : AC2 8) chain A residue 240 type sequence N description binding site for residue GOL A 502 source : AC2 9) chain A residue 253 type sequence H description binding site for residue GOL A 502 source : AC2 10) chain A residue 281 type sequence W description binding site for residue GOL A 502 source : AC2 11) chain A residue 313 type sequence Y description binding site for residue GOL A 502 source : AC2 12) chain A residue 286 type sequence S description binding site for residue GOL A 503 source : AC3 13) chain A residue 239 type sequence C description binding site for residue GOL A 504 source : AC4 14) chain A residue 241 type sequence E description binding site for residue GOL A 504 source : AC4 15) chain A residue 257 type sequence R description binding site for residue GOL A 504 source : AC4 16) chain A residue 342 type sequence E description binding site for residue GOL A 505 source : AC5 17) chain A residue 346 type sequence D description binding site for residue GOL A 505 source : AC5 18) chain A residue 263 type ACT_SITE sequence P description Proton donor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 261 type BINDING sequence L description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 292 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 297 type BINDING sequence L description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 253-293 type prosite sequence HAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGE V description CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElrFLdlvpslqldpaqiyrvtwfisws..........PCfswg....CageV source prosite : PS00903

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