eF-site ID 5chg-AB PDB Code 5chg Chain A, B click to enlarge Title Human DNA polymerase lambda L431A mutant- MgdGTP binary and complex with 6 paired DNA Classification TRANSFERASE/DNA Compound DNA polymerase lambda Source Homo sapiens (Human) (5CHG) Sequence A:  ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASL TTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSG LLCVACGSYRRGKATCGDVDVAITHPDGRSHRGIFSRLLD SLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRL DIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSE HALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYRE PAERDW B:  PVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQ QAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLC VACGSYRRGKATCGDVDVAITHPDGRSHRGIFSRLLDSLR QEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDII VVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHAL STAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAE RDW Description Functional site 1) chain A residue 339 type sequence S description binding site for residue MG A 601 source : AC1 2) chain A residue 341 type sequence I description binding site for residue MG A 601 source : AC1 3) chain A residue 344 type sequence A description binding site for residue MG A 601 source : AC1 4) chain B residue 514 type sequence R description binding site for residue SO4 B 601 source : AC2 5) chain B residue 517 type sequence R description binding site for residue SO4 B 601 source : AC2 6) chain B residue 427 type sequence D description binding site for residue MG B 602 source : AC3 7) chain B residue 429 type sequence D description binding site for residue MG B 602 source : AC3 8) chain B residue 386 type sequence R description binding site for residue DGT B 603 source : AC4 9) chain B residue 416 type sequence G description binding site for residue DGT B 603 source : AC4 10) chain B residue 417 type sequence S description binding site for residue DGT B 603 source : AC4 11) chain B residue 420 type sequence R description binding site for residue DGT B 603 source : AC4 12) chain B residue 426 type sequence G description binding site for residue DGT B 603 source : AC4 13) chain B residue 427 type sequence D description binding site for residue DGT B 603 source : AC4 14) chain B residue 429 type sequence D description binding site for residue DGT B 603 source : AC4 15) chain B residue 505 type sequence Y description binding site for residue DGT B 603 source : AC4 16) chain B residue 506 type sequence F description binding site for residue DGT B 603 source : AC4 17) chain B residue 508 type sequence G description binding site for residue DGT B 603 source : AC4 18) chain B residue 513 type sequence N description binding site for residue DGT B 603 source : AC4 19) chain A residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 20) chain A residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 21) chain A residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 22) chain A residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 23) chain B residue 386 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 24) chain B residue 417 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 25) chain B residue 426 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 26) chain B residue 513 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI2 27) chain A residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 28) chain A residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 29) chain A residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 30) chain B residue 427 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 31) chain B residue 429 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3 32) chain B residue 490 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ source Swiss-Prot : SWS_FT_FI3

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