|
|
eF-site ID
|
5cen-A |
|
PDB Code
|
5cen |
|
Chain
|
A |
|
click to enlarge
|
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Title
|
Crystal structure of DLK (kinase domain) |
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Classification
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TRANSFERASE |
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Compound
|
Mitogen-activated protein kinase kinase kinase 12 |
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Source
|
Homo sapiens (Human) (M3K12_HUMAN) |
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Sequence
|
A: |
LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRD
LKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQG
QLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD
LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAW
MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS
AIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS
FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEK
I
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
232-244 |
| type |
prosite |
| sequence |
IIHRDLKSPNMLI
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKspNMLI
|
| source |
prosite : PS00108
|
|
|
2)
|
chain |
A |
| residue |
236 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
131 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
152 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|