eF-site ID 5cb4-ABCDEF PDB Code 5cb4 Chain A, B, C, D, E, F click to enlarge Title Crystal structure of T2R-TTL-Tivantinib complex Classification STRUCTURAL PROTEIN Compound Tubulin alpha Source ORGANISM_SCIENTIFIC: Sus barbatus; Sequence A:  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK TIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRT GTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYR GDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGV B:  REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSD LQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPF GQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVR KESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPD RIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYC IDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLR FPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQY RALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRM SMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGL KMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGE GMDEMEFTEAESNMNDLVSEYQQYQDA C:  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK TIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRT GTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYR GDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV D:  MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS DLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGP FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLLTVPELT QQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQM LNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGN STAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTE AESNMNDLVSEYQQYQDATAD E:  MEVIELNKCTSGQSFEVILKPPSDPSLEEIQKKLEAAEER RKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEK LAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELK E F:  MYTFVVRDENSSVYAEVSRLLLATGQWKRLRKDNPRFNLM LGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKL IKTSPELSESCTWFPESYVIYPTDEREVFLAAYNRRREGR EGNVWIALISSEASELLDFIDEQGQVHVIQKYLEKPLLLE PGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEPYNSANF QDKTCHLTNHCIQKNYGRYEEGNEMFFEEFNQYLMDALNT TLENSILLQIKHIIRSCLMCIEPAISTKHLHYQSFQLFGF DFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDVAISS VFPLATSIFIKLHH Description Functional site 1) chain A residue 10 type sequence G description binding site for residue GTP A 501 source : AC1 2) chain A residue 11 type sequence Q description binding site for residue GTP A 501 source : AC1 3) chain A residue 12 type sequence A description binding site for residue GTP A 501 source : AC1 4) chain A residue 15 type sequence Q description binding site for residue GTP A 501 source : AC1 5) chain A residue 98 type sequence D description binding site for residue GTP A 501 source : AC1 6) chain A residue 99 type sequence A description binding site for residue GTP A 501 source : AC1 7) chain A residue 100 type sequence A description binding site for residue GTP A 501 source : AC1 8) chain A residue 101 type sequence N description binding site for residue GTP A 501 source : AC1 9) chain A residue 140 type sequence S description binding site for residue GTP A 501 source : AC1 10) chain A residue 143 type sequence G description binding site for residue GTP A 501 source : AC1 11) chain A residue 144 type sequence G description binding site for residue GTP A 501 source : AC1 12) chain A residue 145 type sequence T description binding site for residue GTP A 501 source : AC1 13) chain A residue 146 type sequence G description binding site for residue GTP A 501 source : AC1 14) chain A residue 177 type sequence V description binding site for residue GTP A 501 source : AC1 15) chain A residue 179 type sequence T description binding site for residue GTP A 501 source : AC1 16) chain A residue 183 type sequence E description binding site for residue GTP A 501 source : AC1 17) chain A residue 206 type sequence N description binding site for residue GTP A 501 source : AC1 18) chain A residue 224 type sequence Y description binding site for residue GTP A 501 source : AC1 19) chain A residue 228 type sequence N description binding site for residue GTP A 501 source : AC1 20) chain A residue 231 type sequence I description binding site for residue GTP A 501 source : AC1 21) chain B residue 252 type sequence K description binding site for residue GTP A 501 source : AC1 22) chain A residue 39 type sequence D description binding site for residue CA A 503 source : AC3 23) chain A residue 41 type sequence T description binding site for residue CA A 503 source : AC3 24) chain A residue 44 type sequence G description binding site for residue CA A 503 source : AC3 25) chain A residue 55 type sequence E description binding site for residue CA A 503 source : AC3 26) chain A residue 216 type sequence N description binding site for residue GOL A 504 source : AC4 27) chain A residue 274 type sequence P description binding site for residue GOL A 504 source : AC4 28) chain A residue 275 type sequence V description binding site for residue GOL A 504 source : AC4 29) chain A residue 300 type sequence N description binding site for residue GOL A 504 source : AC4 30) chain B residue 10 type sequence G description binding site for residue GDP B 501 source : AC5 31) chain B residue 11 type sequence Q description binding site for residue GDP B 501 source : AC5 32) chain B residue 12 type sequence C description binding site for residue GDP B 501 source : AC5 33) chain B residue 15 type sequence Q description binding site for residue GDP B 501 source : AC5 34) chain B residue 138 type sequence S description binding site for residue GDP B 501 source : AC5 35) chain B residue 141 type sequence G description binding site for residue GDP B 501 source : AC5 36) chain B residue 142 type sequence G description binding site for residue GDP B 501 source : AC5 37) chain B residue 143 type sequence T description binding site for residue GDP B 501 source : AC5 38) chain B residue 144 type sequence G description binding site for residue GDP B 501 source : AC5 39) chain B residue 171 type sequence P description binding site for residue GDP B 501 source : AC5 40) chain B residue 175 type sequence V description binding site for residue GDP B 501 source : AC5 41) chain B residue 181 type sequence E description binding site for residue GDP B 501 source : AC5 42) chain B residue 204 type sequence N description binding site for residue GDP B 501 source : AC5 43) chain B residue 222 type sequence Y description binding site for residue GDP B 501 source : AC5 44) chain B residue 226 type sequence N description binding site for residue GDP B 501 source : AC5 45) chain B residue 11 type sequence Q description binding site for residue MG B 502 source : AC6 46) chain B residue 177 type sequence D description binding site for residue MG B 502 source : AC6 47) chain B residue 156 type sequence R description binding site for residue MES B 503 source : AC7 48) chain B residue 160 type sequence P description binding site for residue MES B 503 source : AC7 49) chain B residue 161 type sequence D description binding site for residue MES B 503 source : AC7 50) chain B residue 162 type sequence R description binding site for residue MES B 503 source : AC7 51) chain B residue 195 type sequence N description binding site for residue MES B 503 source : AC7 52) chain B residue 196 type sequence T description binding site for residue MES B 503 source : AC7 53) chain B residue 197 type sequence D description binding site for residue MES B 503 source : AC7 54) chain B residue 251 type sequence R description binding site for residue MES B 503 source : AC7 55) chain A residue 179 type sequence T description binding site for residue TIV B 504 source : AC8 56) chain A residue 180 type sequence A description binding site for residue TIV B 504 source : AC8 57) chain A residue 181 type sequence V description binding site for residue TIV B 504 source : AC8 58) chain B residue 236 type sequence V description binding site for residue TIV B 504 source : AC8 59) chain B residue 239 type sequence C description binding site for residue TIV B 504 source : AC8 60) chain B residue 246 type sequence L description binding site for residue TIV B 504 source : AC8 61) chain B residue 248 type sequence A description binding site for residue TIV B 504 source : AC8 62) chain B residue 252 type sequence K description binding site for residue TIV B 504 source : AC8 63) chain B residue 256 type sequence N description binding site for residue TIV B 504 source : AC8 64) chain B residue 257 type sequence M description binding site for residue TIV B 504 source : AC8 65) chain B residue 313 type sequence V description binding site for residue TIV B 504 source : AC8 66) chain B residue 315 type sequence A description binding site for residue TIV B 504 source : AC8 67) chain B residue 347 type sequence N description binding site for residue TIV B 504 source : AC8 68) chain B residue 348 type sequence N description binding site for residue TIV B 504 source : AC8 69) chain B residue 350 type sequence K description binding site for residue TIV B 504 source : AC8 70) chain C residue 10 type sequence G description binding site for residue GTP C 501 source : AC9 71) chain C residue 11 type sequence Q description binding site for residue GTP C 501 source : AC9 72) chain C residue 12 type sequence A description binding site for residue GTP C 501 source : AC9 73) chain C residue 15 type sequence Q description binding site for residue GTP C 501 source : AC9 74) chain C residue 69 type sequence D description binding site for residue GTP C 501 source : AC9 75) chain C residue 98 type sequence D description binding site for residue GTP C 501 source : AC9 76) chain C residue 99 type sequence A description binding site for residue GTP C 501 source : AC9 77) chain C residue 100 type sequence A description binding site for residue GTP C 501 source : AC9 78) chain C residue 101 type sequence N description binding site for residue GTP C 501 source : AC9 79) chain C residue 140 type sequence S description binding site for residue GTP C 501 source : AC9 80) chain C residue 143 type sequence G description binding site for residue GTP C 501 source : AC9 81) chain C residue 144 type sequence G description binding site for residue GTP C 501 source : AC9 82) chain C residue 145 type sequence T description binding site for residue GTP C 501 source : AC9 83) chain C residue 146 type sequence G description binding site for residue GTP C 501 source : AC9 84) chain C residue 177 type sequence V description binding site for residue GTP C 501 source : AC9 85) chain C residue 179 type sequence T description binding site for residue GTP C 501 source : AC9 86) chain C residue 183 type sequence E description binding site for residue GTP C 501 source : AC9 87) chain C residue 206 type sequence N description binding site for residue GTP C 501 source : AC9 88) chain C residue 224 type sequence Y description binding site for residue GTP C 501 source : AC9 89) chain C residue 228 type sequence N description binding site for residue GTP C 501 source : AC9 90) chain C residue 231 type sequence I description binding site for residue GTP C 501 source : AC9 91) chain D residue 252 type sequence K description binding site for residue GTP C 501 source : AC9 92) chain C residue 71 type sequence E description binding site for residue MG C 502 source : AD1 93) chain C residue 39 type sequence D description binding site for residue CA C 503 source : AD2 94) chain C residue 41 type sequence T description binding site for residue CA C 503 source : AD2 95) chain C residue 44 type sequence G description binding site for residue CA C 503 source : AD2 96) chain C residue 55 type sequence E description binding site for residue CA C 503 source : AD2 97) chain D residue 10 type sequence G description binding site for residue GDP D 501 source : AD3 98) chain D residue 11 type sequence Q description binding site for residue GDP D 501 source : AD3 99) chain D residue 12 type sequence C description binding site for residue GDP D 501 source : AD3 100) chain D residue 15 type sequence Q description binding site for residue GDP D 501 source : AD3 101) chain D residue 138 type sequence S description binding site for residue GDP D 501 source : AD3 102) chain D residue 141 type sequence G description binding site for residue GDP D 501 source : AD3 103) chain D residue 143 type sequence T description binding site for residue GDP D 501 source : AD3 104) chain D residue 144 type sequence G description binding site for residue GDP D 501 source : AD3 105) chain D residue 176 type sequence S description binding site for residue GDP D 501 source : AD3 106) chain D residue 181 type sequence E description binding site for residue GDP D 501 source : AD3 107) chain D residue 204 type sequence N description binding site for residue GDP D 501 source : AD3 108) chain D residue 222 type sequence Y description binding site for residue GDP D 501 source : AD3 109) chain D residue 226 type sequence N description binding site for residue GDP D 501 source : AD3 110) chain C residue 179 type sequence T description binding site for residue TIV D 502 source : AD4 111) chain C residue 180 type sequence A description binding site for residue TIV D 502 source : AD4 112) chain C residue 181 type sequence V description binding site for residue TIV D 502 source : AD4 113) chain D residue 246 type sequence L description binding site for residue TIV D 502 source : AD4 114) chain D residue 248 type sequence A description binding site for residue TIV D 502 source : AD4 115) chain D residue 252 type sequence K description binding site for residue TIV D 502 source : AD4 116) chain D residue 253 type sequence L description binding site for residue TIV D 502 source : AD4 117) chain D residue 256 type sequence N description binding site for residue TIV D 502 source : AD4 118) chain D residue 257 type sequence M description binding site for residue TIV D 502 source : AD4 119) chain D residue 313 type sequence V description binding site for residue TIV D 502 source : AD4 120) chain D residue 314 type sequence A description binding site for residue TIV D 502 source : AD4 121) chain D residue 315 type sequence A description binding site for residue TIV D 502 source : AD4 122) chain D residue 316 type sequence I description binding site for residue TIV D 502 source : AD4 123) chain D residue 347 type sequence N description binding site for residue TIV D 502 source : AD4 124) chain D residue 348 type sequence N description binding site for residue TIV D 502 source : AD4 125) chain D residue 350 type sequence K description binding site for residue TIV D 502 source : AD4 126) chain D residue 352 type sequence A description binding site for residue TIV D 502 source : AD4 127) chain D residue 368 type sequence I description binding site for residue TIV D 502 source : AD4 128) chain F residue 74 type sequence K description binding site for residue ACP F 401 source : AD5 129) chain F residue 183 type sequence Q description binding site for residue ACP F 401 source : AD5 130) chain F residue 184 type sequence K description binding site for residue ACP F 401 source : AD5 131) chain F residue 185 type sequence Y description binding site for residue ACP F 401 source : AD5 132) chain F residue 186 type sequence L description binding site for residue ACP F 401 source : AD5 133) chain F residue 198 type sequence K description binding site for residue ACP F 401 source : AD5 134) chain F residue 200 type sequence D description binding site for residue ACP F 401 source : AD5 135) chain F residue 202 type sequence R description binding site for residue ACP F 401 source : AD5 136) chain F residue 222 type sequence R description binding site for residue ACP F 401 source : AD5 137) chain F residue 239 type sequence H description binding site for residue ACP F 401 source : AD5 138) chain F residue 240 type sequence L description binding site for residue ACP F 401 source : AD5 139) chain F residue 241 type sequence T description binding site for residue ACP F 401 source : AD5 140) chain F residue 242 type sequence N description binding site for residue ACP F 401 source : AD5 141) chain F residue 318 type sequence D description binding site for residue ACP F 401 source : AD5 142) chain F residue 330 type sequence I description binding site for residue ACP F 401 source : AD5 143) chain F residue 331 type sequence E description binding site for residue ACP F 401 source : AD5 144) chain A residue 142-148 type prosite sequence GGGTGSG description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG source prosite : PS00227 145) chain B residue 140-146 type prosite sequence GGGTGSG description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG source prosite : PS00227 146) chain E residue 73-82 type prosite sequence AEKREHEREV description STATHMIN_2 Stathmin family signature 2. AEKREHEREV source prosite : PS01041 147) chain E residue 46 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1

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