eF-site ID 5c8y-ABCDEF PDB Code 5c8y Chain A, B, C, D, E, F click to enlarge Title Crystal structure of T2R-TTL-Plinabulin complex Classification STRUCTURAL PROTEIN Compound Tubulin alpha Source ORGANISM_SCIENTIFIC: Sus barbatus; Sequence A:  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK TIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRT GTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYR GDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGV B:  REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSD LQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPF GQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVR KESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPD RIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYC IDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLR FPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQY RALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRM SMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGL KMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGE GMDEMEFTEAESNMNDLVSEYQQYQDA C:  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK TIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRT GTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYR GDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV D:  MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS DLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGP FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLLTVPELT QQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQM LNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGN STAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTE AESNMNDLVSEYQQYQDATAD E:  MEVIELNKCTSGQSFEVILKPPSDPSLEEIQKKLEAAEER RKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEK LAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELK E F:  MYTFVVRDENSSVYAEVSRLLLATGQWKRLRKDNPRFNLM LGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKL IKTSPELSESCTWFPESYVIYPTDEREVFLAAYNRRREGR EGNVWIALISSEASELLDFIDEQGQVHVIQKYLEKPLLLE PGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEPYNSANF QDKTCHLTNHCIQKNYGRYEEGNEMFFEEFNQYLMDALNT TLENSILLQIKHIIRSCLMCIEPAISTKHLHYQSFQLFGF DFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDVAISS VFPLATSIFIKLHH Description Functional site 1) chain A residue 10 type sequence G description binding site for residue GTP A 501 source : AC1 2) chain A residue 11 type sequence Q description binding site for residue GTP A 501 source : AC1 3) chain A residue 12 type sequence A description binding site for residue GTP A 501 source : AC1 4) chain A residue 15 type sequence Q description binding site for residue GTP A 501 source : AC1 5) chain A residue 98 type sequence D description binding site for residue GTP A 501 source : AC1 6) chain A residue 99 type sequence A description binding site for residue GTP A 501 source : AC1 7) chain A residue 100 type sequence A description binding site for residue GTP A 501 source : AC1 8) chain A residue 101 type sequence N description binding site for residue GTP A 501 source : AC1 9) chain A residue 140 type sequence S description binding site for residue GTP A 501 source : AC1 10) chain A residue 143 type sequence G description binding site for residue GTP A 501 source : AC1 11) chain A residue 144 type sequence G description binding site for residue GTP A 501 source : AC1 12) chain A residue 145 type sequence T description binding site for residue GTP A 501 source : AC1 13) chain A residue 146 type sequence G description binding site for residue GTP A 501 source : AC1 14) chain A residue 178 type sequence S description binding site for residue GTP A 501 source : AC1 15) chain A residue 183 type sequence E description binding site for residue GTP A 501 source : AC1 16) chain A residue 206 type sequence N description binding site for residue GTP A 501 source : AC1 17) chain A residue 224 type sequence Y description binding site for residue GTP A 501 source : AC1 18) chain A residue 228 type sequence N description binding site for residue GTP A 501 source : AC1 19) chain A residue 231 type sequence I description binding site for residue GTP A 501 source : AC1 20) chain B residue 252 type sequence K description binding site for residue GTP A 501 source : AC1 21) chain A residue 69 type sequence D description binding site for residue MG A 502 source : AC2 22) chain A residue 71 type sequence E description binding site for residue MG A 502 source : AC2 23) chain B residue 247 type sequence N description binding site for residue MG A 502 source : AC2 24) chain A residue 39 type sequence D description binding site for residue CA A 503 source : AC3 25) chain A residue 41 type sequence T description binding site for residue CA A 503 source : AC3 26) chain A residue 44 type sequence G description binding site for residue CA A 503 source : AC3 27) chain A residue 55 type sequence E description binding site for residue CA A 503 source : AC3 28) chain B residue 10 type sequence G description binding site for residue GDP B 501 source : AC4 29) chain B residue 11 type sequence Q description binding site for residue GDP B 501 source : AC4 30) chain B residue 12 type sequence C description binding site for residue GDP B 501 source : AC4 31) chain B residue 15 type sequence Q description binding site for residue GDP B 501 source : AC4 32) chain B residue 138 type sequence S description binding site for residue GDP B 501 source : AC4 33) chain B residue 141 type sequence G description binding site for residue GDP B 501 source : AC4 34) chain B residue 142 type sequence G description binding site for residue GDP B 501 source : AC4 35) chain B residue 143 type sequence T description binding site for residue GDP B 501 source : AC4 36) chain B residue 144 type sequence G description binding site for residue GDP B 501 source : AC4 37) chain B residue 175 type sequence V description binding site for residue GDP B 501 source : AC4 38) chain B residue 181 type sequence E description binding site for residue GDP B 501 source : AC4 39) chain B residue 204 type sequence N description binding site for residue GDP B 501 source : AC4 40) chain B residue 222 type sequence Y description binding site for residue GDP B 501 source : AC4 41) chain B residue 226 type sequence N description binding site for residue GDP B 501 source : AC4 42) chain B residue 11 type sequence Q description binding site for residue MG B 502 source : AC5 43) chain B residue 177 type sequence D description binding site for residue MG B 502 source : AC5 44) chain B residue 161 type sequence D description binding site for residue MES B 503 source : AC6 45) chain B residue 162 type sequence R description binding site for residue MES B 503 source : AC6 46) chain B residue 195 type sequence N description binding site for residue MES B 503 source : AC6 47) chain B residue 196 type sequence T description binding site for residue MES B 503 source : AC6 48) chain B residue 197 type sequence D description binding site for residue MES B 503 source : AC6 49) chain B residue 251 type sequence R description binding site for residue MES B 503 source : AC6 50) chain A residue 179 type sequence T description binding site for residue PN6 B 504 source : AC7 51) chain B residue 50 type sequence Y description binding site for residue PN6 B 504 source : AC7 52) chain B residue 165 type sequence N description binding site for residue PN6 B 504 source : AC7 53) chain B residue 198 type sequence E description binding site for residue PN6 B 504 source : AC7 54) chain B residue 200 type sequence Y description binding site for residue PN6 B 504 source : AC7 55) chain B residue 236 type sequence V description binding site for residue PN6 B 504 source : AC7 56) chain B residue 237 type sequence T description binding site for residue PN6 B 504 source : AC7 57) chain B residue 239 type sequence C description binding site for residue PN6 B 504 source : AC7 58) chain B residue 240 type sequence L description binding site for residue PN6 B 504 source : AC7 59) chain B residue 250 type sequence L description binding site for residue PN6 B 504 source : AC7 60) chain B residue 253 type sequence L description binding site for residue PN6 B 504 source : AC7 61) chain B residue 257 type sequence M description binding site for residue PN6 B 504 source : AC7 62) chain B residue 314 type sequence A description binding site for residue PN6 B 504 source : AC7 63) chain B residue 315 type sequence A description binding site for residue PN6 B 504 source : AC7 64) chain B residue 316 type sequence I description binding site for residue PN6 B 504 source : AC7 65) chain B residue 368 type sequence I description binding site for residue PN6 B 504 source : AC7 66) chain C residue 10 type sequence G description binding site for residue GTP C 501 source : AC8 67) chain C residue 11 type sequence Q description binding site for residue GTP C 501 source : AC8 68) chain C residue 12 type sequence A description binding site for residue GTP C 501 source : AC8 69) chain C residue 15 type sequence Q description binding site for residue GTP C 501 source : AC8 70) chain C residue 98 type sequence D description binding site for residue GTP C 501 source : AC8 71) chain C residue 99 type sequence A description binding site for residue GTP C 501 source : AC8 72) chain C residue 100 type sequence A description binding site for residue GTP C 501 source : AC8 73) chain C residue 101 type sequence N description binding site for residue GTP C 501 source : AC8 74) chain C residue 140 type sequence S description binding site for residue GTP C 501 source : AC8 75) chain C residue 143 type sequence G description binding site for residue GTP C 501 source : AC8 76) chain C residue 144 type sequence G description binding site for residue GTP C 501 source : AC8 77) chain C residue 145 type sequence T description binding site for residue GTP C 501 source : AC8 78) chain C residue 146 type sequence G description binding site for residue GTP C 501 source : AC8 79) chain C residue 178 type sequence S description binding site for residue GTP C 501 source : AC8 80) chain C residue 183 type sequence E description binding site for residue GTP C 501 source : AC8 81) chain C residue 206 type sequence N description binding site for residue GTP C 501 source : AC8 82) chain C residue 224 type sequence Y description binding site for residue GTP C 501 source : AC8 83) chain C residue 228 type sequence N description binding site for residue GTP C 501 source : AC8 84) chain C residue 231 type sequence I description binding site for residue GTP C 501 source : AC8 85) chain D residue 252 type sequence K description binding site for residue GTP C 501 source : AC8 86) chain C residue 71 type sequence E description binding site for residue MG C 502 source : AC9 87) chain C residue 39 type sequence D description binding site for residue CA C 503 source : AD1 88) chain C residue 41 type sequence T description binding site for residue CA C 503 source : AD1 89) chain C residue 44 type sequence G description binding site for residue CA C 503 source : AD1 90) chain C residue 55 type sequence E description binding site for residue CA C 503 source : AD1 91) chain D residue 10 type sequence G description binding site for residue GDP D 501 source : AD2 92) chain D residue 11 type sequence Q description binding site for residue GDP D 501 source : AD2 93) chain D residue 12 type sequence C description binding site for residue GDP D 501 source : AD2 94) chain D residue 15 type sequence Q description binding site for residue GDP D 501 source : AD2 95) chain D residue 138 type sequence S description binding site for residue GDP D 501 source : AD2 96) chain D residue 141 type sequence G description binding site for residue GDP D 501 source : AD2 97) chain D residue 142 type sequence G description binding site for residue GDP D 501 source : AD2 98) chain D residue 143 type sequence T description binding site for residue GDP D 501 source : AD2 99) chain D residue 144 type sequence G description binding site for residue GDP D 501 source : AD2 100) chain D residue 176 type sequence S description binding site for residue GDP D 501 source : AD2 101) chain D residue 181 type sequence E description binding site for residue GDP D 501 source : AD2 102) chain D residue 204 type sequence N description binding site for residue GDP D 501 source : AD2 103) chain D residue 222 type sequence Y description binding site for residue GDP D 501 source : AD2 104) chain D residue 226 type sequence N description binding site for residue GDP D 501 source : AD2 105) chain D residue 134 type sequence Q description binding site for residue PN6 D 502 source : AD3 106) chain D residue 165 type sequence N description binding site for residue PN6 D 502 source : AD3 107) chain D residue 167 type sequence F description binding site for residue PN6 D 502 source : AD3 108) chain D residue 198 type sequence E description binding site for residue PN6 D 502 source : AD3 109) chain D residue 200 type sequence Y description binding site for residue PN6 D 502 source : AD3 110) chain D residue 236 type sequence V description binding site for residue PN6 D 502 source : AD3 111) chain D residue 237 type sequence T description binding site for residue PN6 D 502 source : AD3 112) chain D residue 239 type sequence C description binding site for residue PN6 D 502 source : AD3 113) chain D residue 240 type sequence L description binding site for residue PN6 D 502 source : AD3 114) chain D residue 246 type sequence L description binding site for residue PN6 D 502 source : AD3 115) chain D residue 253 type sequence L description binding site for residue PN6 D 502 source : AD3 116) chain D residue 257 type sequence M description binding site for residue PN6 D 502 source : AD3 117) chain D residue 314 type sequence A description binding site for residue PN6 D 502 source : AD3 118) chain D residue 315 type sequence A description binding site for residue PN6 D 502 source : AD3 119) chain D residue 316 type sequence I description binding site for residue PN6 D 502 source : AD3 120) chain D residue 352 type sequence A description binding site for residue PN6 D 502 source : AD3 121) chain D residue 368 type sequence I description binding site for residue PN6 D 502 source : AD3 122) chain F residue 74 type sequence K description binding site for residue ACP F 401 source : AD4 123) chain F residue 183 type sequence Q description binding site for residue ACP F 401 source : AD4 124) chain F residue 184 type sequence K description binding site for residue ACP F 401 source : AD4 125) chain F residue 186 type sequence L description binding site for residue ACP F 401 source : AD4 126) chain F residue 198 type sequence K description binding site for residue ACP F 401 source : AD4 127) chain F residue 200 type sequence D description binding site for residue ACP F 401 source : AD4 128) chain F residue 202 type sequence R description binding site for residue ACP F 401 source : AD4 129) chain F residue 222 type sequence R description binding site for residue ACP F 401 source : AD4 130) chain F residue 239 type sequence H description binding site for residue ACP F 401 source : AD4 131) chain F residue 241 type sequence T description binding site for residue ACP F 401 source : AD4 132) chain F residue 242 type sequence N description binding site for residue ACP F 401 source : AD4 133) chain F residue 318 type sequence D description binding site for residue ACP F 401 source : AD4 134) chain F residue 330 type sequence I description binding site for residue ACP F 401 source : AD4 135) chain F residue 331 type sequence E description binding site for residue ACP F 401 source : AD4 136) chain F residue 333 type sequence N description binding site for residue ACP F 401 source : AD4 137) chain B residue 140-146 type prosite sequence GGGTGSG description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG source prosite : PS00227 138) chain A residue 142-148 type prosite sequence GGGTGSG description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG source prosite : PS00227 139) chain E residue 73-82 type prosite sequence AEKREHEREV description STATHMIN_2 Stathmin family signature 2. AEKREHEREV source prosite : PS01041 140) chain E residue 46 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links