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Functional site
| 1) | chain | A |
| residue | 150 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 501 | |
| source | : AC1 | |
| 2) | chain | A |
| residue | 154 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 501 | |
| source | : AC1 | |
| 3) | chain | A |
| residue | 212 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 501 | |
| source | : AC1 | |
| 4) | chain | A |
| residue | 215 | |
| type | ||
| sequence | H | |
| description | binding site for residue ZN A 501 | |
| source | : AC1 | |
| 5) | chain | A |
| residue | 166 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 502 | |
| source | : AC2 | |
| 6) | chain | A |
| residue | 169 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 502 | |
| source | : AC2 | |
| 7) | chain | A |
| residue | 196 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 502 | |
| source | : AC2 | |
| 8) | chain | A |
| residue | 201 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 502 | |
| source | : AC2 | |
| 9) | chain | A |
| residue | 238 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 503 | |
| source | : AC3 | |
| 10) | chain | A |
| residue | 241 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 503 | |
| source | : AC3 | |
| 11) | chain | A |
| residue | 260 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 503 | |
| source | : AC3 | |
| 12) | chain | A |
| residue | 263 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 503 | |
| source | : AC3 | |
| 13) | chain | A |
| residue | 253 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 504 | |
| source | : AC4 | |
| 14) | chain | A |
| residue | 257 | |
| type | ||
| sequence | H | |
| description | binding site for residue ZN A 504 | |
| source | : AC4 | |
| 15) | chain | A |
| residue | 289 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 504 | |
| source | : AC4 | |
| 16) | chain | A |
| residue | 293 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 504 | |
| source | : AC4 | |
| 17) | chain | A |
| residue | 332 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 505 | |
| source | : AC5 | |
| 18) | chain | A |
| residue | 337 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 505 | |
| source | : AC5 | |
| 19) | chain | A |
| residue | 352 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 505 | |
| source | : AC5 | |
| 20) | chain | A |
| residue | 361 | |
| type | ||
| sequence | G | |
| description | binding site for residue ZN A 505 | |
| source | : AC5 | |
| 21) | chain | A |
| residue | 365 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 506 | |
| source | : AC6 | |
| 22) | chain | A |
| residue | 368 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 506 | |
| source | : AC6 | |
| 23) | chain | A |
| residue | 373 | |
| type | ||
| sequence | H | |
| description | binding site for residue ZN A 506 | |
| source | : AC6 | |
| 24) | chain | A |
| residue | 377 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 506 | |
| source | : AC6 | |
| 25) | chain | A |
| residue | 418 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 507 | |
| source | : AC7 | |
| 26) | chain | A |
| residue | 421 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 507 | |
| source | : AC7 | |
| 27) | chain | A |
| residue | 436 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 507 | |
| source | : AC7 | |
| 28) | chain | A |
| residue | 441 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 507 | |
| source | : AC7 | |
| 29) | chain | A |
| residue | 446 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 508 | |
| source | : AC8 | |
| 30) | chain | A |
| residue | 449 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 508 | |
| source | : AC8 | |
| 31) | chain | A |
| residue | 457 | |
| type | ||
| sequence | C | |
| description | binding site for residue ZN A 508 | |
| source | : AC8 | |
| 32) | chain | A |
| residue | 461 | |
| type | ||
| sequence | H | |
| description | binding site for residue ZN A 508 | |
| source | : AC8 | |
| 33) | chain | A |
| residue | 57 | |
| type | ||
| sequence | Q | |
| description | binding site for residue SO4 A 509 | |
| source | : AC9 | |
| 34) | chain | A |
| residue | 58 | |
| type | ||
| sequence | N | |
| description | binding site for residue SO4 A 509 | |
| source | : AC9 | |
| 35) | chain | A |
| residue | 161 | |
| type | ||
| sequence | K | |
| description | binding site for residue SO4 A 509 | |
| source | : AC9 | |
| 36) | chain | A |
| residue | 163 | |
| type | ||
| sequence | R | |
| description | binding site for residue SO4 A 509 | |
| source | : AC9 | |
| 37) | chain | A |
| residue | 211 | |
| type | ||
| sequence | K | |
| description | binding site for residue SO4 A 509 | |
| source | : AC9 | |
| 38) | chain | A |
| residue | 217 | |
| type | ||
| sequence | T | |
| description | binding site for residue SO4 A 509 | |
| source | : AC9 | |
| 39) | chain | A |
| residue | 455 | |
| type | ||
| sequence | R | |
| description | binding site for residue SO4 A 509 | |
| source | : AC9 | |
| 40) | chain | A |
| residue | 186 | |
| type | ||
| sequence | V | |
| description | binding site for residue GOL A 510 | |
| source | : AD1 | |
| 41) | chain | A |
| residue | 187 | |
| type | ||
| sequence | L | |
| description | binding site for residue GOL A 510 | |
| source | : AD1 | |
| 42) | chain | A |
| residue | 189 | |
| type | ||
| sequence | P | |
| description | binding site for residue GOL A 510 | |
| source | : AD1 | |
| 43) | chain | A |
| residue | 207 | |
| type | ||
| sequence | E | |
| description | binding site for residue GOL A 510 | |
| source | : AD1 | |
| 44) | chain | A |
| residue | 208 | |
| type | ||
| sequence | F | |
| description | binding site for residue GOL A 510 | |
| source | : AD1 | |
| 45) | chain | A |
| residue | 227 | |
| type | ||
| sequence | H | |
| description | binding site for residue GOL A 511 | |
| source | : AD2 | |
| 46) | chain | A |
| residue | 230 | |
| type | ||
| sequence | A | |
| description | binding site for residue GOL A 511 | |
| source | : AD2 | |
| 47) | chain | A |
| residue | 252 | |
| type | ||
| sequence | Q | |
| description | binding site for residue GOL A 511 | |
| source | : AD2 | |
| 48) | chain | A |
| residue | 147 | |
| type | ||
| sequence | Y | |
| description | binding site for residue CL A 512 | |
| source | : AD3 | |
| 49) | chain | A |
| residue | 183 | |
| type | ||
| sequence | W | |
| description | binding site for residue CL A 512 | |
| source | : AD3 | |
| 50) | chain | A |
| residue | 226 | |
| type | ||
| sequence | L | |
| description | binding site for residue CL A 512 | |
| source | : AD3 | |
| 51) | chain | A |
| residue | 229 | |
| type | ||
| sequence | I | |
| description | binding site for residue CL A 512 | |
| source | : AD3 | |
| 52) | chain | A |
| residue | 201-285 | |
| type | ZN_FING | |
| sequence |
CPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHD PQLGY |
|
| description | RING-type 0; atypical | |
| source | Swiss-Prot : SWS_FT_FI1 | |
| 53) | chain | A |
| residue | 277 | |
| type | MOD_RES | |
| sequence | F | |
| description | Phosphothreonine => ECO:0000269|PubMed:18957282 | |
| source | Swiss-Prot : SWS_FT_FI10 | |
| 54) | chain | A |
| residue | 429 | |
| type | CROSSLNK | |
| sequence | G | |
| description | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:27534820 | |
| source | Swiss-Prot : SWS_FT_FI11 | |
| 55) | chain | A |
| residue | 298-353 | |
| type | ZN_FING | |
| sequence |
IKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGC GAGLLPEPDQRKVTCE |
|
| description | RING-type 1 => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI2 | |
| 56) | chain | A |
| residue | 373-437 | |
| type | ZN_FING | |
| sequence |
HEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKN GGCMHMKCP |
|
| description | IBR-type => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI3 | |
| 57) | chain | A |
| residue | 298 | |
| type | BINDING | |
| sequence | I | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 58) | chain | A |
| residue | 301 | |
| type | BINDING | |
| sequence | L | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 59) | chain | A |
| residue | 313 | |
| type | BINDING | |
| sequence | N | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 60) | chain | A |
| residue | 317 | |
| type | BINDING | |
| sequence | Q | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 61) | chain | A |
| residue | 320 | |
| type | BINDING | |
| sequence | A | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 62) | chain | A |
| residue | 323 | |
| type | BINDING | |
| sequence | C | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 63) | chain | A |
| residue | 349 | |
| type | BINDING | |
| sequence | K | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 64) | chain | A |
| residue | 353 | |
| type | BINDING | |
| sequence | E | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 65) | chain | A |
| residue | 433 | |
| type | BINDING | |
| sequence | H | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221 | |
| source | Swiss-Prot : SWS_FT_FI6 | |
| 66) | chain | A |
| residue | 392 | |
| type | BINDING | |
| sequence | R | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917 | |
| source | Swiss-Prot : SWS_FT_FI7 | |
| 67) | chain | A |
| residue | 397 | |
| type | BINDING | |
| sequence | A | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917 | |
| source | Swiss-Prot : SWS_FT_FI7 | |
| 68) | chain | A |
| residue | 420 | |
| type | BINDING | |
| sequence | R | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917 | |
| source | Swiss-Prot : SWS_FT_FI7 | |
| 69) | chain | A |
| residue | 425 | |
| type | BINDING | |
| sequence | V | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917 | |
| source | Swiss-Prot : SWS_FT_FI7 | |
| 70) | chain | A |
| residue | 428 | |
| type | BINDING | |
| sequence | N | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917 | |
| source | Swiss-Prot : SWS_FT_FI7 | |
| 71) | chain | A |
| residue | 437 | |
| type | BINDING | |
| sequence | P | |
| description | BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917 | |
| source | Swiss-Prot : SWS_FT_FI7 | |
| 72) | chain | A |
| residue | 65 | |
| type | MOD_RES | |
| sequence | S | |
| description | Phosphoserine; by PINK1 => ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25474007 | |
| source | Swiss-Prot : SWS_FT_FI8 | |
| 73) | chain | A |
| residue | 235 | |
| type | MOD_RES | |
| sequence | N | |
| description | Phosphothreonine; by PINK1 => ECO:0000269|PubMed:18957282 | |
| source | Swiss-Prot : SWS_FT_FI9 | |