eF-site ID 5bt4-C PDB Code 5bt4 Chain C click to enlarge Title Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe Classification TRANSCRIPTION Compound Bromodomain-containing protein 4 Source Homo sapiens (Human) (BRD4_HUMAN) Sequence C:  NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPF QQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQ ECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE LPTE Description (1)  Bromodomain-containing protein 4 Functional site 1) chain C residue 121 type sequence N description binding site for residue 2LO A 201 source : AC1 2) chain C residue 124 type sequence E description binding site for residue 2LO A 201 source : AC1 3) chain C residue 127 type sequence Q description binding site for residue 2LO A 201 source : AC1 4) chain C residue 128 type sequence D description binding site for residue 2LO A 201 source : AC1 5) chain C residue 82 type sequence P description binding site for residue 2LO B 201 source : AC3 6) chain C residue 83 type sequence F description binding site for residue 2LO B 201 source : AC3 7) chain C residue 91 type sequence K description binding site for residue 2LO B 201 source : AC3 8) chain C residue 92 type sequence L description binding site for residue 2LO B 201 source : AC3 9) chain C residue 94 type sequence L description binding site for residue 2LO B 201 source : AC3 10) chain C residue 140 type sequence N description binding site for residue 2LO B 201 source : AC3 11) chain C residue 146 type sequence I description binding site for residue 2LO B 201 source : AC3 12) chain C residue 76 type sequence K description binding site for residue EDO B 202 source : AC4 13) chain C residue 78 type sequence Q description binding site for residue 2LO C 201 source : AC5 14) chain C residue 81 type sequence W description binding site for residue 2LO C 201 source : AC5 15) chain C residue 82 type sequence P description binding site for residue 2LO C 201 source : AC5 16) chain C residue 84 type sequence Q description binding site for residue 2LO C 201 source : AC5 17) chain C residue 85 type sequence Q description binding site for residue 2LO C 201 source : AC5 18) chain C residue 149 type sequence M description binding site for residue 2LO C 201 source : AC5 19) chain C residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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